Abstract: A method for the preparation of 4-(nitrophenyl)-dihydro-pyridines by reacting a benzaldehyde with an acetoacetate and reacting the resulting benzylidene derivative with an enamine derivative. Both reactions are catalyzed by dimethylamine benzoate or p-anisate.

Abstract: This invention relates to diltiazem analogs having the formula: ##STR1## where the substituents are defined in the specification. These compounds are useful in treating cardiovascular problems. The invention also relates to a process for preparing the compounds and to pharmaceutical compositions containing the compounds.

Abstract: Compounds having a angiotensine II antagonistic activity ##STR1## Compounds of formula (I), wherein R, R.sub.1, R.sub.2, R.sub.3, X and Z groups have the meanings given in the specification and are endowed with AII antagonistic properties.

Abstract: (+)-Cis-3-(acetoxy)-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4-methoxyphe nyl)-1,5-benzothiazepin-4(5H)-one hydrochloride is prepared by N-alkylation of (+)-cis-3-hydroxy-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one with dimethylaminoethyl chloride and K.sub.2 CO.sub.3 in toluene/water, addition of a solubilizing agent and in the presence of a phase-transfer catalyst, the toluene phase being directly subjected to the final O-- acetylation.

Abstract: Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.

Abstract: 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives of formula (I): ##STR1## and pharmaceutically acceptable salts thereof having in vitro high affinity and selectively for .alpha..sub.1 receptors and in vivo good and long lasting hypotensive activty, with negligible side-effects; processes for the preparation thereof and pharmaceutical compositions therefrom.

Abstract: This invention relates to a series of thiazole derivatives having the general formula ##STR1## The compounds of the invention have an interesting diuretic activity and low toxicity.

Abstract: A pharmaceutical compound characterized by a delayed release of the therapeutically active component, comprising a sulfonic type ion exchange resin and cis(.+-.)-3-acetyloxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyp henyl)-1,5-benzothiazepin-4(5H)one, or cis(.+-.)-3-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphe nyl)-1,5-benzothiazepin-4(5H)one as a therapeutically active compound.A process for the preparation of the active compound.A pharmaceutical composition including said active compound, and use of said composition for the prophylaxis and therapy of acute and chronical coronary insufficiency and of arterial hypertension.

Abstract: 3-(3-Hydroxybutoxy)-1-butanol having formula II and its stereoisomers and optical isomers, at the pure state, are described ##STR1## Processes for the purification of II and for the preparation of a pure diastereoisomer of II are described. Pharmaceutical compositions containing as the active ingredient compound II alone or combined with the isomeric ethers 4-(3-hydroxybutoxy)-2-butanol I and 3-(3-hydroxy-1-methylpropoxy)-1-butanol III.

Abstract: The dl-.alpha.-2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid, which is a useful intermediate for the synthesis of pharmacologically active compounds, is separated in its enantiomers through salification with L-lysine with high yields and optical purities.

Abstract: The invention provides novel substituted 2-phenylamino-imidazolines-(2) having hypotensive, bradycardizing and diuretic activities.

Abstract: The invention provides novel 4-aryl-5-aminoalkyl-1,3-dioxol-2-ones having hypocholesterolemic, hypolipemic, antiulcer, antihistaminic and antiserotoninic activities.

Abstract: The invention provides novel esters of 1-(p-hydroxyphenyl)-2-(1'-methyl-2'-phenoxyethylamino)-1-propanol having better properties as vascular dilatators, than the corresponding 1-(p-hydroxyphenyl)-2-(1'-methyl-2-phenoxyethylamino)-1-propanol.

Abstract: 2,2-Disubstituted-1,3-benzodioxoles having anti-inflammatory, analgesic, antipyretic and antitussive action, inhibition or excitation of the central nervous system, local anaesthetic, anti-arrhythmic and anti-hypotensive action, and action inhibiting the aggregation of platelets.

Abstract: The invention provides novel 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their salts and complexes which have activity on the central nervous system, the cardio-vascular system, and anti-inflammatory, adrenolytic and anti-ulcer activity.

Abstract: 1,4-Benzodioxan derivatives of the formula: ##STR1## IN WHICH Ar is an aryl group and X is --OR, where R is hydroxyalkyl, aminoalkyl, or aminoalkoxyalkyl, or ##STR2## where R.sub.1 and R.sub.2 are hydrogen, hydroxyl, alkyl, aryl, or aralkyl or are joined together to form an alkylene group which may contain an oxygen, sulphur or nitrogen hetero atom, have interesting pharmacological properties.

Abstract: The invention provides a new class of aminoalkoxyphenoxyalkenones having interesting pharmacological properties.

Abstract: 2,2 Disubstituted-1,3-benzodioxoles having anti-flammatory, analgesic, anti-pyretic and anti-tussive action, inhibition or excitation of the central nervous system, local anaesthetic, anti-arrhythmic and hypotensive action, and action inhibiting the aggregation of platelets.

Abstract: 2-Substituted benzodioxoles are useful as pharmaceuticals having e.g. anti-inflammatory, analgesic, antipyrretic, antitussive, C.N.S. depressant, local anaesthetic, antiarrythmic, antihistaminic action and hypolipidic action.

Abstract: 1,3-Disubstituted-3-aroylpropanes of the formula: ##EQU1## and their salts, in which Ar represents an aryl residue unsubstituted or substituted by halogen, polyhalogeno alkyl or lower alkoxy; R.sup.1 represents an hydroxy, acyloxy, carbamoyloxy, alkylcarbamoyloxy, dialkylcarbamoyloxy, aroyloxy, alkoxy, aryloxy, or cyano group or an amino group of the formula: ##EQU2## which can be the residue of a secondary amine, a tertiary amine, or of a heterocyclic amine; and ##EQU3## represents the residue of a secondary amine, a tertiary amine, or of a heterocyclic amine, have interesting properties as analgesic agents, anti-arrhythmic agents, and central nervous depressants.