Abstract: A preparation and application device for implant materials consisting of at least one powder or granulate component and one liquid component, which are to be prepared immediately before use, is disclosed. The device comprises a first container which holds the powder or granulate component in a sterile, closed-off manner; and a second container which holds the liquid component in a sterile, closed-off manner and which can be connected to the first container. A mixing shaft which is hollow and located on a mixing mechanism is guided out of the first container is hollow and joins a hand pump for producing negative pressure at its external end. A measuring device which indicates the negative pressure can be connected to the first container and the housing of the hand pump is configured in such a way that it is suitable for use as a handle for moving the mixing shaft.

Abstract: The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be mixed, comprising in one end region a sealable through-opening that can optionally be provided with a discharge unit for the paste-like material to be prepared, and a piston which can be inserted into the other, opposite, open end. The piston is displaceable in the cylinder and seals against the inner wall of the cylinder. The piston is penetrated by an elongated mixing shaft sealed against the piston, and a mixing mechanism is disposed at the cylinder inside-end of the mixing shaft and a handle disposed at the cylinder outside-end of the mixing shaft.

Abstract: The powdery component of the implant material consists essentially of a mixture of hydroxyl apatite powder and calcium sulfate powder, wherein the hydroxyl apatite powder consists of synthetically prepared, precipitated crystalline nanoparticles of high purity, which have a crystal size of 10-20 nm width and 50-60 nm length. The specific absorbing BET surface area of the nanocrystals is preferably 100-150 m2/g.

Abstract: The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be mixed, comprising in one end region a sealable through-opening that can optionally be provided with a discharge unit for the paste-like material to be prepared, and a piston which can be inserted into the other, opposite, open end. The piston is displaceable in the cylinder and seals against the inner wall of the cylinder. The piston is penetrated by an elongated mixing shaft sealed against the piston, and a mixing mechanism is disposed at the cylinder inside-end of the mixing shaft and a handle disposed at the cylinder outside-end of the mixing shaft.

Abstract: The invention relates to a preparation and application device (10) for implant materials consisting of at least one powder or granulate component and one liquid component, which are to be prepared immediately before use. Said device comprises a first container (12) which holds the powder or granulate component in a sterile, closed-off manner; and a second container (54) which holds the liquid component in a sterile, closed-off manner and which can be connected to the first container (12). Means are provided for producing an overflow connection between the two containers, on a mixing mechanism (30) which is located on a mixing shaft (28) that is guided out of the container in a sealed manner. The first container is configured in such a way that it can he connected to a negative pressure source.

Abstract: The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties correspond to those of autologous bone transplantation.

Abstract: The invention relates to an implant material which is based on a composite material of calcium phosphate ceramic particles and bioabsorbable polymer, in which the proportion of calcium phosphate ceramic particles is at least 50% by weight and the particles are joined to one another by polymer bridges to give a three-dimensional open-pore structure in which the particle surfaces are covered with polymer to the extent of not more than 50%. This implant material is distinguished by particularly favorable growing-in and healing-in properties.

Abstract: New flavanone derivatives of the formula I ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO.sub.2 and/or substituted by a methylenedioxy group, and the alkyl, alkoxy and acyl groups each have 1-7 C atoms, but wherein the HO group is only in the 6-position if at least one of the radicals Ar.sup.1 and Ar.sup.2 is substituted phenyl, and the phosphoric acid esters thereof and the salts of these compounds display antiallergic effects. Salts of the I-phosphoric acid esters with aminoglycoside antibiotics are outstandingly stable and possess advantageous kinetics of liberation.

Abstract: A resorbable porous tricalcium phosphate, in which the pores are sealed with a filler mixture of an antibiotic and a filler, in particular an amino acid, is particularly advantageous for use in the preparation of bone cements.

Abstract: The invention relates to an implantable medicament depot comprising physiologically acceptable excipients and at least one delayed release active compound which is a chemotherapeutic of the gyrase inhibitor type.The depot can be used for combating infections.

Abstract: A drug depot, which can be implanted in the body, for the controlled, delayed release of cytostatics, comprises a synthetic material based on polyacrylates and/or polymethacrylates containing a cytostatic and at least one amino acid. The depot can be used in a particularly advantageous manner for the local control of tumors.

Abstract: Flavonoid phosphates of aminoglycoside antibiotics are useful sparingly soluble salts, e.g., for achieving a depot effect.

Abstract: A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C.sub.2-16 .alpha.-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.

Abstract: By adding amino acids to antibiotic-containing compositions having as a base polymethacrylates, acrylates or a mixture thereof, reproducible improved antibiotic-release properties are achieved.

Abstract: By adding amino acids to antibiotic-containing compositions having as a base polymethacrylates, acrylates or a mixture thereof, reproducible improved antibiotic-release properties are achieved.

Abstract: Novel .beta.-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R.sup.1 is hydrogen, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-yl, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiadiazol-5-yl; and n is an integer from 0 to 8; or a readily-cleavable ester or physiologically-acceptable salt thereof.