Abstract: Frangible valve means within a flexible tube. The valve means comprises a tubular portion having closed ends, and an elongated, generally rigid member carried on the exterior of the closed end and positioned within the flexible tube. Frangible means are provided to permit the opening of the tubular portion adjacent the closed end by rupture of an area of weakness by manual manipulation of the elongated member from outside of the flexible tube. In accordance with this invention, the flexible tube defines an inner end flange, while the tubular end portion of the valve means defines, at its end opposite to the closed end, a retention flange. The retention flange includes a cylindrical wall positioned generally coaxially to the tube and surrounding the periphery of the inner end flange. The cylindrical wall, in turn, carries an annular closure flange enclosing and retaining the inner end flange. A method of assembling the above structure is also disclosed.

Abstract: Injection sites are provided for injecting substances such as medicaments into systems that are feeding parenteral fluid to a patient, which injection sites have injection ports that are thermoplastically sealed into the injection site in a manner that is simpler, faster, less expensive, and more readily automated than other assemblies. The assembly includes a vibratory energy seal of the non-thermoplastic port within a countersunk thermoplastic seat.