Patents by Inventor Emília P.T. Leitão

Emília P.T. Leitão has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of synthesizing factor Xa inhibitors
    Patent number: 8987463
    Abstract: Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: March 24, 2015
    Assignees: Millennium Pharmaceuticals, Inc., Portola Pharmaceuticals, Inc.
    Inventors: Anjali Pandey, Emilia P. T. Leitao, Jose Rato, Zhiguo Jake Song
  • Methods of synthesizing factor Xa inhibitors
    Patent number: 8394964
    Abstract: Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: March 12, 2013
    Assignees: Millennium Pharmaceuticals, Inc., Portola Pharmaceuticals, Inc.
    Inventors: Anjali Pandey, Emilia P. T. Leitao, Jose Rato, Zhiguo Jake Song
  • METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS
    Publication number: 20110319627
    Abstract: Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
    Type: Application
    Filed: December 15, 2010
    Publication date: December 29, 2011
    Inventors: Anjali Pandey, Emilia P. T. Leitao, Jose Rato, Zhiguo Jake Song
  • METHODS AND INTERMEDIATES FOR SYNTHESIS OF SELECTIVE DPP-IV INHIBITORS
    Publication number: 20100087658
    Abstract: Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.
    Type: Application
    Filed: March 5, 2008
    Publication date: April 8, 2010
    Applicant: Phenomix Corporation
    Inventors: David Alan Campbell, Emília P.T. Leitão, Zhen-Ping Wu, Peng Wang