Abstract: Embodiments disclosed herein relate to a package comprising a plurality of chambers, each of the plurality of chambers comprising a solid unit dosage comprising an active ingredient, wherein the package is configured to provide an individualized delivery of the active ingredient in different concentrations of the active ingredient to a human or an animal. The effective amount of active ingredient is adjusted in the solid unit dosage according to the size or weight of solid unit dosage. The manufacture of the solid unit dosage comprises mixing of the active substance with pharmaceutically acceptable additives, followed by hot or cold extrusion and spheronization. The solid unit dosages can be manufactured without the use of a tablet press, lyophilization or molding. Solid unit dosages with various drug loads or many drug strengths simultaneously are produced in one batch without further processing.

Abstract: The invention relates to a self-microemulsifying drug delivery system (“SMEDDS”) of mitotane, with enhanced bioavailability. More particularly the invention provides a mitotane oily formulation comprising propylene glycol monocaprylate (10 to 30% w/w), propylene glycol dicaprate (20 to 60% w/w) and polyoxyethylenesorbitanne monooleate (10 to 30% w/w).

Abstract: The invention relates to a self-microemulsifying drug delivery system (“SMEDDS”) of mitotane, with enhanced bioavailability. More particularly the invention provides a mitotane oily formulation comprising propylene glycol monocaprylate (10 to 30% w/w), propylene glycol dicaprate (20 to 60% w/w) and polyoxyethylenesorbitanne monooleate (10 to 30% w/w).