Patents by Inventor Emad Sarofim
Emad Sarofim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240062373Abstract: A method for compensating defective partitions of a microfluidic chip and a sample processing system for performing the method are disclosed. The microfluidic chip includes at least one array of partitions. The method includes generating image data of the microfluidic chip by imaging the microfluidic chip with an imaging device, providing a mask for at least one area of partitions to a data processing unit, applying the mask to (a) the image data, (b) at least one feature extracted from the image data, or (c) at least one value extracted from the image data, to generate masked data, and generating an analytical result for the sample using the masked data.Type: ApplicationFiled: August 17, 2023Publication date: February 22, 2024Inventors: Wouter Johannes Pattje, Emad Sarofim, Michael Zeder
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Patent number: 11759888Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.Type: GrantFiled: May 27, 2021Date of Patent: September 19, 2023Assignee: Roche Molecular Systems, Inc.Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
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Patent number: 11645755Abstract: A method for determining sample container characteristics is presented. The method comprises providing first image data representing a first image of a sample container in a first scenario, wherein in the first scenario, a first illumination condition comprising a sample container background illumination is applied to the sample container; providing second image data representing a second image of the sample container in a second scenario, wherein in the second scenario, a second illumination condition different from the first is applied to the sample container; determining a mask from the first image that indicates a sub-image section of the first image comprising a sample container representation in the first image; determining sub-image data from the second image containing a sample container representation in the second image by applying the mask to the second image; and determining the sample container characteristics from an image data analysis comprising image sub-image data data analysis.Type: GrantFiled: March 10, 2021Date of Patent: May 9, 2023Assignee: Roche Diagnostics Operations, Inc.Inventor: Emad Sarofim
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Publication number: 20220062903Abstract: The present disclosure relates to a method for separating an aqueous liquid comprising biological material into at least two cavities, the use of a polysiloxane having at least one hydroxy group in such a method, as well as a system for separating an aqueous liquid into at least two cavities.Type: ApplicationFiled: August 31, 2021Publication date: March 3, 2022Inventor: Emad Sarofim
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Patent number: 11169061Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.Type: GrantFiled: August 16, 2019Date of Patent: November 9, 2021Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
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Publication number: 20210287370Abstract: A method for determining sample container characteristics is presented. The method comprises providing first image data representing a first image of a sample container in a first scenario, wherein in the first scenario, a first illumination condition comprising a sample container background illumination is applied to the sample container; providing second image data representing a second image of the sample container in a second scenario, wherein in the second scenario, a second illumination condition different from the first is applied to the sample container; determining a mask from the first image that indicates a sub-image section of the first image comprising a sample container representation in the first image; determining sub-image data from the second image containing a sample container representation in the second image by applying the mask to the second image; and determining the sample container characteristics from an image data analysis comprising image sub-image data data analysis.Type: ApplicationFiled: March 10, 2021Publication date: September 16, 2021Applicant: Roche Diagnostics Operations, Inc.Inventor: Emad Sarofim
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Publication number: 20210283714Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.Type: ApplicationFiled: May 27, 2021Publication date: September 16, 2021Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
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Patent number: 11067565Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.Type: GrantFiled: March 16, 2018Date of Patent: July 20, 2021Assignee: Roche Molecular Systems, Inc.Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
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Patent number: 11052484Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.Type: GrantFiled: May 17, 2018Date of Patent: July 6, 2021Assignee: Roche Molecular Systems, Inc.Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
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Publication number: 20200298234Abstract: The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.Type: ApplicationFiled: June 8, 2020Publication date: September 24, 2020Inventors: Stephan KORNER, Emad SAROFIM, Goran SAVATIC, Marko SIMIC
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Publication number: 20200033240Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.Type: ApplicationFiled: August 16, 2019Publication date: January 30, 2020Applicant: Roche Diagnostics Operations, Inc.Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
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Patent number: 10456777Abstract: A pressure transmission liquid for a cellular analyzer, a system for transferring a liquid cellular sample for analysis by a cellular analyzer, and a method for transferring a liquid cellar sample for analysis are disclosed. The pressure transmission liquid includes an aqueous solution which is isotonic and substantially non-conductive characteristics. The cellular analyzer includes a pipetting module having a pipetting tip, a device for positioning the pipetting module, a sensor for detecting a liquid level of a liquid cellular sample to be analyzed, a pressure transmission liquid, and a pressure transmission liquid conduit connected to the pipetting tip and the pressure transmission liquid reservoir.Type: GrantFiled: April 15, 2016Date of Patent: October 29, 2019Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Martin Kopp, Emad Sarofim
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Patent number: 10436685Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.Type: GrantFiled: January 27, 2017Date of Patent: October 8, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
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Publication number: 20190239975Abstract: The present disclosure relates to a system for the thermally controlled processing of biological material in a liquid sample in a multiwell plate using magnetic particles. Also disclosed is a corresponding method for the thermally controlled processing of biological material in a liquid sample.Type: ApplicationFiled: January 25, 2019Publication date: August 8, 2019Inventors: Roland Bernet, Claudio Cherubini, Pius Hermann, Emad Sarofim
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Patent number: 10251589Abstract: A system for withdrawing blood from a body part that avoids formation of a drop of blood on the skin surface of the body part after blood removal. The system includes a collecting unit to withdraw blood, a lancing member configured for insertion into the body part and having a capillary to collect blood, and a pressure piece configured to apply pressure to the body part and having an actuator operably connected thereto. The pressure piece is movable relative to a support configured to exert pressure on the body part, and the actuator is configured to reduce the compressive force of the pressure piece after removing an amount of blood, whereby forming a drop of blood on the skin surface of the body part can be avoided.Type: GrantFiled: July 22, 2016Date of Patent: April 9, 2019Assignee: ROCHE DIABETES CARE, INC.Inventors: Stephan Korner, Rainer Jaeggi, Patrick Griss, Emad Sarofim, Irio Giuseppe Calasso
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Publication number: 20180333806Abstract: According to the present invention, a system (1; 1?) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1?) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4?) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4?) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1?) is provided.Type: ApplicationFiled: May 17, 2018Publication date: November 22, 2018Inventors: Claudio Cherubini, Andreas Drechsler, Reto Huesser, Emad Sarofim
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Publication number: 20180209964Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.Type: ApplicationFiled: March 16, 2018Publication date: July 26, 2018Applicant: Roche Molecular Systems, Inc.Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
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Patent number: 9956559Abstract: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.Type: GrantFiled: December 20, 2016Date of Patent: May 1, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Claudio Cherubini, Roger Iten, Emad Sarofim, Kurt Schildknecht
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Patent number: 9939429Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.Type: GrantFiled: July 8, 2014Date of Patent: April 10, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
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Publication number: 20180010990Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.Type: ApplicationFiled: January 27, 2017Publication date: January 11, 2018Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic