Abstract: Exemplary systems, apparatus and methods, and computer-accessible medium can be provided for effectuating one or more image-based physiology measurements. For example, it is possible to position a reference object within an imaging field of view of an X-ray radiation source, and in a vicinity of at least one section of a body or a target object. It is further possible to provide X-ray radiation to such portion of the body or the target object, as well as to the reference object(s). Further, it is possible to generate at least one X-ray image of the portion(s) that contains an image of the reference object based on (i) a first radiation provided from the portion, and (ii) a second radiation provided from the reference object.

Abstract: Aspects of the disclosure relate to the use of an optical detection scheme enabling multiple imaging sub-systems concurrently optimized for retrieving multiple characterization modalities. The feature described is an offset illumination and detection arrangement for a multimodal imaging probe. The imaging probe comprises multiple waveguides disposed within a torque-transfer coil, distally terminating at longitudinally separated positions. A first waveguide may have focusing optics for focused illumination and/or detection. Any number of other waveguides may be deployed for illumination and/or detection having no focusing optics. The disclosure enables high-fidelity multimodal imaging systems.

Abstract: Intravascular sensing systems and extravascular sensing systems are both integral tools in the interventional cardiology workflow but remain relatively disconnected & disparate sources of information. Effective utilization of the information between these disparate systems can be cumbersome for a clinician and result in reduced treatment efficacy, increased procedure times and loss of information. The present disclosure overcomes these limitations & enables optimized interventional workflows and improved coronary assessments.

Abstract: Provided herein are systems and methods for registering extravascular and intravascular data.

Abstract: Exemplary apparatus, system, method and computer-accessible medium for controlling a generation or an output of an electromagnetic radiation can be provided. For example, with a device, directing the electromagnetic radiation, and using a controller, controlling the device to move the electromagnetic radiation at a rate of motion. The device and/or the controller can provide information regarding the rate of motion. Further, with a computer, it is possible to receive the information, and effectuate the generation or the output of the electromagnetic radiation if the rate of motion is greater than a predetermined rate based on the information.

Abstract: An exemplary capsule apparatus is provided, which includes a capsule having a first end and a second end opposite to the first end. A terminal portion of the capsule at the first end has a tapered end that has a section which curves toward a center of the terminal portion. Additionally, a tethered capsule apparatus includes a capsule configured to provide imaging optics having an orifice provided at least one end thereof. A tether having a proximal end and a distal end is also be provided The distal end of the tether has an enlarged end portion that is greater than a width of a neighboring portion, and the enlarged end portion can be positioned and configured to be secured in the orifice.

Abstract: Systems and methods for detecting features, outputting feature representations, determining measurements, and combinations thereof using machine-learned algorithms are provided. In some embodiments, first sample data from a first characterization modality and second sample data from a second characterization modality are provided to a machine-learned algorithm. Improved feature detection, feature representation, and measurement may be realized by using multimodal data with a machine-learned algorithm. In some embodiments, a first characterization modality is an interferometric modality and a second characterization modality is a spectroscopic modality. A first characterization modality may be optical coherence tomography and a second characterization modality may be a diffuse spectroscopy modality, such as near-infrared spectroscopy. Sample data may be intraluminal and/or vascular data useful in characterizing a vascular system of a subject, such as a human.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: Aspects of the disclosure relate to the use of an optical detection scheme enabling multiple imaging sub-systems concurrently optimized for retrieving multiple characterization modalities. The feature described is an offset illumination and detection arrangement for a multimodal imaging probe. The imaging probe comprises multiple waveguides disposed within a torque-transfer coil, distally terminating at longitudinally separated positions. A first waveguide may have focusing optics for focused illumination and/or detection. Any number of other waveguides may be deployed for illumination and/or detection having no focusing optics. The disclosure enables high-fidelity multimodal imaging systems.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: An exemplary capsule apparatus is provided, which includes a capsule having a first end and a second end opposite to the first end. A terminal portion of the capsule at the first end has a tapered end that has a section which curves toward a center of the terminal portion. Additionally, a tethered capsule apparatus includes a capsule configured to provide imaging optics having an orifice provided at least one end thereof. A tether having a proximal end and a distal end is also be provided. The distal end of the tether has an enlarged end portion that has a width that is greater than a width of a neighboring portion, and the enlarged end portion can be positioned and configured to be secured in the orifice.

Abstract: Disclosed herein are characterization systems. A characterization system may comprise a stationary unit. The characterization system may comprise a rotary unit. optically connected to the stationary unit (e.g., via a FORJ) if present. The rotary unit may comprise a first optical channel, a second optical channel, and a light detector for detecting light for a first characterization modality. The light detector may be a camera, interferometer, or spectrometer. The first optical channel and/or the second optical channel may comprise a single mode optical fiber, a multimode optical fiber, or multiple waveguides. The first optical channel may be optically connected to the light detector. The stationary unit, if present, may be optically connected to the rotary unit at least in part with the second optical channel. The second optical channel may be used to detect light for a second characterization modality, with a detector in the stationary unit.

Abstract: The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Abstract: The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Abstract: The present disclosure provides an OCT imaging system having a variety of advantages. In particular, the OCT system of the present disclosure may provide a more intuitive interface, more efficient usage of controls, and a greater ability to view OCT imaging data.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.