Patents by Inventor Emanuel Grunberg

Emanuel Grunberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4238589
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: December 9, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Patent number: 4045487
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: August 30, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Patent number: 4038289
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl: R.sub.2 is phenyl or substituted phenyl: and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: July 26, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Patent number: 4018884
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl: R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: April 19, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Patent number: 3996356
    Abstract: Antibacterial compositions containing 5-sulfanilamido-3,4-dimethylisoxazole and 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine are described.
    Type: Grant
    Filed: January 14, 1972
    Date of Patent: December 7, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Emanuel Grunberg
  • Patent number: 3993761
    Abstract: 2,4-Diamino-5-(3-alkoxy-4,5-methylenedioxybenzyl)-pyrimidines, such as, for example, 2,4-diamino-5-(3-methoxy-4,5-methylenedioxybenzyl)pyrimidine, prepared from the corresponding benzaldehydes, are described. The end products are useful as potentiators of the antibacterial activity of sulfonamides, as well as antibiotics.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Emanuel Grunberg, Max Hoffer
  • Patent number: 3969373
    Abstract: Compounds of the formula ##SPC1##Wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: June 26, 1975
    Date of Patent: July 13, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Patent number: 3962435
    Abstract: 2,4-Diamino-5-(3-alkoxy-4,5-methylenedioxybenzyl)pyrimidines, such as, for example, 2,4-diamino-5-(3-methoxy-4,5-methylenedioxybenzyl)pyrimidine, prepared from the corresponding benzaldehydes, are described. The end products are useful as potentiators of the antibacterial activity of sulfonamides, as well as antibiotics.
    Type: Grant
    Filed: December 9, 1974
    Date of Patent: June 8, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Emanuel Grunberg, Max Hoffer
  • Patent number: 3952091
    Abstract: Compositions useful for conducting a plurality of different radioimmuno-assays simultaneously and methods for preparing same. The compositions radioimmunoassaya a plurality of labeled antigens and their respective antibodies present in selected concentrations so that the response curves observed for each antigen are essentially superimposable on the response curve of all other antigens present in the composition. Particularly preferred compositions include a mixture of radiolabeled morphine, a radiolabeled 5- or 5,5-substituted barbituric acid, i.e., secobarbital and their respective antibodies useful for performing a bivalent radioimmunoassay and a mixture of radiolabeled morphine, radiolabeled amphetamine, a radiolabeled 5- or 5,5-substituted barbituric acid and their respective antibodies useful for performing a trivalent radioimmunoassay.
    Type: Grant
    Filed: October 23, 1974
    Date of Patent: April 20, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Emanuel Grunberg, Magdalena Usategui Gomez