Abstract: The invention relates to the field of additive manufacturing (3D printing) of hydrogels and biological materials. The invention discloses a 3D bioprinting system of multiple hydrogels and biological materials each of which is loaded in a different syringe, using a single extrusion nozzle. It also refers to the syringe adapter, to the uses and applications of the 3D bioprinting system and syringe adapter and to a process for extrusion of hydrogels, biological materials or mixtures thereof.

Abstract: This invention consists of a method for the development of personalized target anticancer therapies based on aptamers and through the systemic modeling of an individual in microfluidic devices. This invention is embodied in microfluidic devices, connections, systems, and methods for the development specific aptamers for the relevant complex biological environment targets. In a first mode, the invention provides methods for the development of target therapies which involves the maintenance of target cancerous cells in co-culture with non-target and non-cancerous cells by using microfluidic devices modularly arranged in closed systems for the development of aptamers. In a second mode, the invention provides a method for the development of target therapies, which includes the maintenance of target cells in co-culture with non-target cells by using microfluidic devices modularly arranged in closed systems.