Patents by Inventor Emi Nakashima

Emi Nakashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immortalized vascular adventital cell line
    Patent number: 7316926
    Abstract: To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful substance using the immortalized capillary pericyte line. Cerebral tissue of a transgenic rat carrying the large T antigen gene of SV40 thermo-sensitive mutant line tsA58 is homogenized and the resultant brain capillaries are treated with protease, thus obtained brain capillary cells are subcultured to establish an immortalized cell that expresses SV40 thermo-sensitive large T antigen, PDGF receptor ?, and Angiopoietin-1. In addition, the immortalized vascular pericyte line has ability to deposit calcium on matrix by dense culture.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: January 8, 2008
    Assignee: Japan Science and Technology Agency
    Inventors: Hisashi Iizasa, Kenji Hattori, Emi Nakashima, Tetsuya Terasaki, Masuo Obinata
  • Immortalized vascular adventital cell line
    Publication number: 20030175953
    Abstract: To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful substance using the immortalized capillary pericyte line. Cerebral tissue of a transgenic rat carrying the large T antigen gene of SV40 thermo-sensitive mutant line tsA58 is homogenized and the resultant brain capillaries are treated with protease, thus obtained brain capillary cells are subcultured to establish an immortalized cell that expresses SV40 thermo-sensitive large T antigen, PDGF receptor &bgr;, and Angiopoietin-1. In addition, the immortalized vascular pericyte line has ability to deposit calcium on matrix by dense culture.
    Type: Application
    Filed: August 16, 2002
    Publication date: September 18, 2003
    Inventors: Hisashi Iizasa, Kenji Hattori, Emi Nakashima, Tetsuya Terasaki, Masuo Obinata