Patents by Inventor Emi Nishimura
Emi Nishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230338307Abstract: The present disclosure pertains to provision of: a tear layer stabilizer; a prophylactic agent, ameliorating agent, and therapeutic agent for corneal epithelial disorders; a prophylactic agent, ameliorating agent, and therapeutic agent for meibomian gland dysfunction; and a prophylactic agent, ameliorating agent, and therapeutic agent for dry eye. More specifically, provided are a tear layer stabilizer, a prophylactic agent, ameliorating agent, and therapeutic agent for corneal epithelial disorders, and a prophylactic agent, ameliorating agent, and therapeutic agent for meibomian gland dysfunction, and a prophylactic agent, ameliorating agent, and therapeutic agent for dry eye, each of which composition contains apocynin as an active ingredient.Type: ApplicationFiled: September 24, 2021Publication date: October 26, 2023Inventor: Emi NISHIMURA
-
Publication number: 20220331389Abstract: The present invention pertains to: the provision of a method for promoting skin wound healing and a composition to be used for promoting skin wound healing; the provision of a method useful for preventing or ameliorating ulcers and bedsores or a composition therefor; the provision of a method for preventing skin aging and a composition to be used for preventing skin aging; the provision of a composition useful for preventing or ameliorating skin damage caused by an anticancer agent; and, furthermore, the provision of a method for enhancing the regeneration ability of epidermal stem cells and a composition for enhancing the regeneration ability of epidermal stem cells.Type: ApplicationFiled: March 26, 2020Publication date: October 20, 2022Inventor: Emi NISHIMURA
-
Patent number: 11475578Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.Type: GrantFiled: June 19, 2019Date of Patent: October 18, 2022Assignee: TEIKYO UNIVERSITYInventors: Junichi Kotoku, Takuya Hirose, Daisuke Nanba, Emi Nishimura
-
Patent number: 11298372Abstract: The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used.Type: GrantFiled: May 28, 2020Date of Patent: April 12, 2022Assignee: National University Corporation Tokyo Medical and Dental UniversityInventors: Emi Nishimura, Hiroyuki Matsumura
-
Publication number: 20210201508Abstract: Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.Type: ApplicationFiled: June 19, 2019Publication date: July 1, 2021Applicant: TEIKYO UNIVERSITYInventors: Junichi Kotoku, Takuya Hirose, Daisuke Nanba, Emi Nishimura
-
Publication number: 20200289541Abstract: The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used.Type: ApplicationFiled: May 28, 2020Publication date: September 17, 2020Inventors: Emi NISHIMURA, Hiroyuki Matsumura
-
Patent number: 10702544Abstract: The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used.Type: GrantFiled: January 11, 2017Date of Patent: July 7, 2020Assignee: National University Corporation Tokyo Medical and Dental UniversityInventors: Emi Nishimura, Hiroyuki Matsumura
-
Publication number: 20180325940Abstract: The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used.Type: ApplicationFiled: January 11, 2017Publication date: November 15, 2018Inventors: Emi NISHIMURA, Hiroyuki MATSUMURA
-
Publication number: 20100206748Abstract: Provided is a stress measurement kit that is economical and that has good sensitivity. The stress measurement kit for measuring a stress level of a test subject includes: (A) a sensor chip including an electrically insulating substrate, and an electrode system that is placed on the electrically insulating substrate and that includes at least a working electrode and a counter electrode, wherein glucose dehydrogenase (GDH) and an electron mediator are immobilized on the working electrode; (B) a polysaccharide; and (C) a sensor body including an insertion hole into which the sensor chip is inserted, an electrical measurement means that is electrically connected to the electrode system of the sensor chip in a state where the sensor chip is inserted into the insertion hole, and a conversion means by which a current value or an electric quantity measured by the electrical measurement means is converted into an amylase activity value.Type: ApplicationFiled: July 31, 2008Publication date: August 19, 2010Applicant: NIPRO CORPORATIONInventors: Mitsuhiro Morita, Toshiaki Baba, Hiroshi Yoshida, Emi Nishimura
-
Publication number: 20090215685Abstract: The present invention aims to provide a method for inhibiting hair depigmentation and a method for inhibiting hair loss, in which hair depigmentation and hair loss are inhibited by collagen XVII.Type: ApplicationFiled: February 22, 2008Publication date: August 27, 2009Applicant: National University Corporation Kanazawa UniversityInventors: Emi Nishimura, Hiroshi Shimizu, Shintaro Tanimura, Yuko Tadokoro, Daisuke Sawamura, Wataru Nishie