Patents by Inventor Emiko MIHARA

Emiko MIHARA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neutralizing Antibody for Tooth Regeneration Treatment Targeting USAG-1 Molecule
    Publication number: 20220259298
    Abstract: Provided are: an antibody which specifically binds to and neutralizes USAG-1 or an antigen-binding fragment thereof; and a pharmaceutical composition containing the antibody or the antigen-binding fragment.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 18, 2022
    Applicants: Kyoto University, University of Fukui, Osaka University
    Inventors: Katsu Takahashi, Manabu Sugai, Yoshihito Tokita, Junichi Takagi, Emiko Mihara
  • Method for producing Wnt protein and method for storing Wnt protein
    Patent number: 11293007
    Abstract: A method for producing a Wnt protein-afamin complex, the method comprising the steps of culturing Wnt protein-expressing cells in a culture medium containing a purified afamin or a recombinant afamin or co-culturing Wnt protein-expressing cells and recombinant afamin-expressing cells or culturing cells expressing both a Wnt protein and afamin; obtaining the culture supernatant; and optionally performing affinity purification to obtain the Wnt protein-afamin complex from the culture supernatant.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: April 5, 2022
    Assignee: OSAKA UNIVERSITY
    Inventors: Junichi Takagi, Emiko Mihara, Akira Kikuchi
  • Method for producing Wnt protein and method for storing Wnt protein
    Patent number: 10550364
    Abstract: Provided is a novel method for producing a Wnt protein, which method comprises (1) a step of performing affinity purification targeting afamin to obtain a Wnt protein from a culture product, and/or (2) a step of performing affinity purification to obtain a Wnt protein in the form of a complex with afamin from a culture product. The method enables a Wnt protein having high Wnt activity to be produced in a simple and brief manner without use of special equipment.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: February 4, 2020
    Assignee: OSAKA UNIVERSITY
    Inventors: Junichi Takagi, Emiko Mihara, Akira Kikuchi
  • METHOD FOR PRODUCING WNT PROTEIN AND METHOD FOR STORING WNT PROTEIN
    Publication number: 20190390160
    Abstract: Provided is a novel method for producing a Wnt protein, which method comprises (1) a step of performing affinity purification targeting afamin to obtain a Wnt protein from a culture product, and/or (2) a step of performing affinity purification to obtain a Wnt protein in the form of a complex with afamin from a culture product. The method enables a Wnt protein having high Wnt activity to be produced in a simple and brief manner without use of special equipment.
    Type: Application
    Filed: September 10, 2019
    Publication date: December 26, 2019
    Applicant: OSAKA UNIVERSITY
    Inventors: Junichi TAKAGI, Emiko MIHARA, Akira KIKUCHI
  • METHOD FOR PRODUCING WNT PROTEIN AND METHOD FOR STORING WNT PROTEIN
    Publication number: 20170355953
    Abstract: Provided is a novel method for producing a Wnt protein, which method comprises (1) a step of performing affinity purification targeting afamin to obtain a Wnt protein from a culture product, and/or (2) a step of performing affinity purification to obtain a Wnt protein in the form of a complex with afamin from a culture product. The method enables a Wnt protein having high Wnt activity to be produced in a simple and brief manner without use of special equipment.
    Type: Application
    Filed: December 24, 2015
    Publication date: December 14, 2017
    Applicant: OSAKA UNIVERSITY
    Inventors: Junichi TAKAGI, Emiko MIHARA, Akira KIKUCHI