Patents by Inventor Emiko Shinohara

Emiko Shinohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrohalide
    Patent number: 4634790
    Abstract: A process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrohalide, which comprises subjecting 3-benzyl-6-carboxymethyl-2,5-diketopiperazine to partial hydrolysis with a strong acid in a solvent mixture of methanol and water.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: January 6, 1987
    Assignee: Ajinomoto Co., Inc.
    Inventors: Emiko Shinohara, Katsumi Sugiyama, Masanao Ozaki, Keizo Matsuda
  • Method of preparing methyl ester and its hydrochloride
    Patent number: 4618695
    Abstract: A method of preparing .alpha.-L-phenylalanine methyl ester and its hydrochloride, which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine .beta.-methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentrated hydrochloric acid and water, 0 to 20% by volume of methanol, 8 to 55% by volume of concentrated hydrochloric acid and water (balance) in a concentration from 0.01 mol/dl to 0.3 mol/dl; holding the solution at 0.degree. to 60.degree. C. to effect intramolecular ester exchange reaction and crystallize out the formed .alpha.-L-aspartyl-L-phenylalanine methyl ester as its hydrochloride; isolating the hydrochloride; and obtaining, when required, the free ester by neutralization with an alkali, is disclosed.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: October 21, 1986
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoichi Ozawa, Shinichi Kishimoto, Emiko Shinohara, Tadashi Takemoto, Chikahiko Eguchi
  • Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride
    Patent number: 4606854
    Abstract: A method for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine dimethyl ester in a mixture of 0-10% (v/v) methanol, 8-55% (v/v) of concentrated hydrochloric acid, and water (remainder) to a concentration of 0.01 mol/dl to 0.30 mol/dl; holding the resulting solution at one or more temperatures between 0.degree. and 60.degree. C. for a time sufficient for crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride to precipitate out, and isolating the crystals. The hydrochloride may then be treated with alkali to yield .alpha.-L-aspartyl-L-phenylalanine methyl ester.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: August 19, 1986
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoichi Ozawa, Shinichi Kishimoto, Emiko Shinohara, Tadashi Takemoto, Chikahiko Eguchi