Patents by Inventor Emilia Entcheva

Emilia Entcheva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3D BIOPHOTONIC DEVICES FOR OPTICAL ELECTROPHYSIOLOGY AND METHODS OF USE THEREOF
    Publication number: 20240117292
    Abstract: Embodiments of the instant disclosure relate to compositions and methods of use thereof that allow for faster integration of acute cardiac pacing experiments compared to the direct genetic modification methods currently in use. Embodiments provided herein provide for spheroids that may be stored, transported, and deployed on site to confer optical pacing of cardiac tissue for use in high-throughput functional in vitro screening assays.
    Type: Application
    Filed: November 15, 2023
    Publication date: April 11, 2024
    Inventors: Emilia ENTCHEVA, Christianne Joan CHUA
  • Automated system for high-throughput all-optical dynamic electrophysiology
    Patent number: 11680904
    Abstract: Bio-photonic devices or target cells and cell cultures including bio-photonic devices and target cells are provided. Methods of preparing cell cultures including bio-photonic devices and target cells are also provided. Methods of analyzing the electrophysiology of target cells using the cell cultures are provided. Systems for analyzing the electrophysiology of target cells are also provided.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: June 20, 2023
    Assignee: The George Washington University
    Inventors: Emilia Entcheva, Aleksandra Klimas
  • KITS AND METHODS FOR PERFORMING OPTICAL DYNAMIC CLAMP ON EXCITABLE CELLS
    Publication number: 20220010279
    Abstract: The present disclosure is directed to kits and methods for performing optical dynamic clamping on an excitable cell. In some embodiments, the excitable cell is selected from the group consisting of a neuron, a muscle cell and an excitable cell derived from an induced Pluripotent Stem Cell (IPSC). In a specific embodiment, the muscle cell is a cardiomyocyte.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 13, 2022
    Inventors: Bonnie QUACH, Trine KROGH-MADSEN, David J. CHRISTINI, Emilia ENTCHEVA
  • AUTOMATED SYSTEM FOR HIGH-THROUGHPUT ALL-OPTICAL DYNAMIC ELECTROPHYSIOLOGY
    Publication number: 20190137398
    Abstract: Bio-photonic devices or target cells and cell cultures including bio-photonic devices and target cells are provided. Methods of preparing cell cultures including bio-photonic devices and target cells are also provided. Methods of analyzing the electrophysiology of target cells using the cell cultures are provided. Systems for analyzing the electrophysiology of target cells are also provided.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 9, 2019
    Applicant: The George Washington University
    Inventors: Emilia ENTCHEVA, Aleksandra KLIMAS
  • OPTICAL INTERROGATION AND CONTROL OF DYNAMIC BIOLOGICAL FUNCTIONS
    Publication number: 20170350874
    Abstract: An imaging system for imaging live biological systems comprises a detector array (12a) having an optical axis (X-X) and arranged to detect light and output detector signals, a support (10) arranged so support a biological system on the optical axis, an illuminating light source (16) located off the optical axis and arranged to direct at least partially-coherent light towards the biological system, and processing means (18) arranged to receive the detector signals and generate image data.
    Type: Application
    Filed: December 30, 2015
    Publication date: December 7, 2017
    Inventors: Emilia Entcheva, Gil Bub
  • OPTICAL CONTROL OF CARDIAC FUNCTION
    Publication number: 20130274838
    Abstract: The invention features an optically-controlled biological device that includes a biological component comprising a non-excitable cell expressing a light-gated ion channel protein and capable of forming gap junction channels with a target cell, and an optical stimulation unit.
    Type: Application
    Filed: October 18, 2011
    Publication date: October 17, 2013
    Applicant: The Research Foundation of State University of New York
    Inventors: Emilia Entcheva, Zhiheng Jia, Zhongju Lu, Harold Bien, Ira S. Cohen