Patents by Inventor Emilia Leitao

Emilia Leitao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the esterification of a carbothioic acid
    Patent number: 9670246
    Abstract: A process for preparing compounds of formula [II] by esterification of the C-17 hydroxyl group of 6?,9?-difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioic acid, the compound of formula [I] comprises treating compound [I] with a slight excess of an acyl chloride of general formula R—COCl, where R represents —CH2CH3, —CH2CH2CH3 or —CH(CH3)2, in an inert solvent, in the presence of a tertiary amine. Preferably the process is carried out using pyridine in the presence of acetone at a temperature of from 5° C. to ?20° C.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: June 6, 2017
    Assignee: Hovione Inter Ltd.
    Inventors: Luis Sobral, Dionisio Martin, William Heggie, Emilia Leitäo
  • Process for obtaining steroidal phosphate compounds
    Patent number: 8445471
    Abstract: A process for obtaining 21-disodium phosphate pregnane derivative compounds of formula (I), wherein X?R?H or X?F and R=?-CH3 or X?F and R=?-CH3: comprises spray drying a solution comprising compound of formula (I).
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: May 21, 2013
    Assignee: Hovione Inter Limited
    Inventors: Luis Sobral, Filipe Gaspar, William Heggie, Emilia Leitao, Jose Rafael Antunes
  • PROCESS FOR OBTAINING STEROIDAL PHOSPHATE COMPOUNDS
    Publication number: 20100240916
    Abstract: A process for obtaining 21-disodium phosphate pregnane derivative compounds of formula (I), wherein X?R?H or X?F and R=?-CH3 or X?F and R=?-CH3 comprises spray drying a solution comprising compound of formula (I).
    Type: Application
    Filed: May 16, 2008
    Publication date: September 23, 2010
    Applicant: HOVIONE INTER LIMITED
    Inventors: Luis Sobral, Filipe Gaspar, William Heggie, Emilia Leitao, Jose Rafael Antunes
  • Process for the Esterification of a Carbothioic Acid
    Publication number: 20070287846
    Abstract: A process for preparing compounds of formula [II] by esterification of the C-17 hydroxyl group of 6?,9?-difluoro-11?,17?-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioic acid, the compound of formula [I] comprises treating compound [I] with a slight excess of an acyl chloride of general formula R—COCl, where R represents —CH2CH3, —CH2CH2CH3 or —CH(CH3)2, in an inert solvent, in the presence of a tertiary amine. Preferably the process is carried out using pyridine in the presence of acetone at a temperature of from 5° C. to ?20° C.
    Type: Application
    Filed: December 2, 2004
    Publication date: December 13, 2007
    Inventors: Luis Sobral, Dionisio Martin, William Heggie, Emilia Leitao