Patents by Inventor Emilia S. Olson

Emilia S. Olson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides whose uptake by cells is controllable
    Patent number: 10259845
    Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: April 16, 2019
    Assignee: The Regents of the University of California
    Inventors: Tao Jiang, Emilia S. Olson, Michael Whitney, Roger Tsien
  • PEPTIDES WHOSE UPTAKE BY CELLS IS CONTROLLABLE
    Publication number: 20170029466
    Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
    Type: Application
    Filed: June 29, 2015
    Publication date: February 2, 2017
    Inventors: Tao Jiang, Emilia S. Olson, Michael Whitney, Roger Tsien
  • Peptides whose uptake by cells is controllable
    Patent number: 9072792
    Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: July 7, 2015
    Assignee: The Regents of the University of California
    Inventors: Tao Jiang, Emilia S. Olson, Michael Whitney, Roger Tsien
  • PEPTIDES WHOSE UPTAKE BY CELLS IS CONTROLLABLE
    Publication number: 20120014873
    Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 19, 2012
    Applicant: The Regents of the University of California
    Inventors: Tao Jiang, Emilia S. Olson, Michael Whitney, Roger Y. Tsien
  • Peptides whose uptake by cells is controllable
    Patent number: 7985401
    Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: July 26, 2011
    Assignee: The Regents of the University of California
    Inventors: Tao Jiang, Emilia S. Olson, Michael Whitney, Roger Tsien