Patents by Inventor Emilie Despagnet Smith

Emilie Despagnet Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3 di-substituted cyclobutane or azetidine derivatives as hematopoietic prostaglandin D synthase inhibitors
    Patent number: 11053234
    Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: July 6, 2021
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: David Norman Deaton, Yu Guo, Ashley Paul Hancock, Christie Schulte, Barry George Shearer, Emilie Despagnet Smith, Eugene L. Stewart, Stephen Andrew Thomson
  • 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS
    Publication number: 20190241554
    Abstract: A compound of formula (I) wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 8, 2019
    Inventors: David Norman DEATON, Yu GUO, Ashley Paul HANCOCK, Christie SCHULTE, Barry George SHEARER, Emilie Despagnet SMITH, Eugene L. STEWART, Stephen Andrew THOMSON
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7888512
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: February 15, 2011
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • SYNTHESIS OF NICOTINE DERIVATIVES FROM NICOTINE
    Publication number: 20090234129
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: May 27, 2009
    Publication date: September 17, 2009
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7553968
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: June 30, 2009
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7501520
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 10, 2009
    Assignee: North Carlina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • SYNTHESIS OF NICOTINE DERIVATIVES FROM NICOTINE
    Publication number: 20080154041
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: March 7, 2008
    Publication date: June 26, 2008
    Applicant: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7361768
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: April 22, 2008
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7179917
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: February 20, 2007
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 7132545
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: November 7, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith
  • Regioselective halogenation of nicotine and substituted nicotines
    Patent number: 7067672
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: June 27, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Florence Fevrier, Emilie Despagnet Smith
  • Synthesis of nicotine derivatives from nicotine
    Patent number: 6995265
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: February 7, 2006
    Assignee: North Carolina State University
    Inventors: Daniel L. Comins, Emilie Despagnet Smith