Patents by Inventor Emilie Smith

Emilie Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Two-Component, Water-Based Lamination Adhesive and Use of the Same to Bond Substrates and Foams
    Publication number: 20220002600
    Abstract: A water comprising, two component polyurethane dispersion adhesive comprising an anionic polyester polyurethane resin and a solvent-free liquid aliphatic polyisocyanate cross-linker. The dispersion can be reactivated one or more times for edge bonding a flexible sheet material onto a substrate having a main surface, a peripheral surface and an edge connecting the main surface and the peripheral surface.
    Type: Application
    Filed: September 23, 2021
    Publication date: January 6, 2022
    Inventors: Sandeep Kothawade, Girdhari Kumar, Abhijit Hirekerur, Umesh Harkal, Emilie Smith-Heberer
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7875724
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 25, 2011
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • REGIOSPECIFIC SYNTHESIS OF NICOTINE DERIVATIVES
    Publication number: 20100113785
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Application
    Filed: January 15, 2010
    Publication date: May 6, 2010
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7671209
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: March 2, 2010
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • Regiospecific synthesis of nicotine derivatives
    Publication number: 20080108822
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 8, 2008
    Inventors: Laura King, Emilie Smith, Daniel Comins
  • Benzene, Pyridine, and Pyridazine Derivatives
    Publication number: 20080076800
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, R4, R5, RO, m, and p are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 27, 2008
    Inventors: Kenneth Huang, Thomas Barta, Emilie Smith, Steven Hall, James Veal
  • Pyrimidine and Pyrazine Derivatives
    Publication number: 20080070930
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R0, R3, R7, n, Q1, Q2, Y, and X1-X3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 20, 2008
    Inventors: Kenneth Huang, Emilie Smith, James Veal
  • Purine, Pyrimidine, and Azaindole Derivatives
    Publication number: 20080070933
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I, wherein A, R7, X1, X2, X3, Y, and n are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 20, 2008
    Inventors: Kenneth Huang, James Veal, Emilie Smith, Wei Ma
  • Isoquinoline, Quinazoline and Phthalazine Derivatives
    Publication number: 20080070935
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R0, R5, R6, R7, n, Q1-Q5, Y, and X1-X3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 20, 2008
    Inventors: Kenneth Huang, James Veal, Thomas Barta, Emilie Smith, Wei Ma, Andy Ommen
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7304160
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 4, 2007
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • REGIOSELECTIVE HALOGENATION OF NICOTINE AND SUBSTITUTED NICOTINES
    Publication number: 20070112195
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Application
    Filed: January 16, 2007
    Publication date: May 17, 2007
    Inventors: Daniel Comins, Florence Fevrier, Emilie Smith
  • SYNTHESIS OF NICOTINE DERIVATIVES FROM NICOTINE
    Publication number: 20070021469
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: September 28, 2006
    Publication date: January 25, 2007
    Inventors: Daniel Comins, Emilie Smith
  • Regiospecific Synthesis of Nicotine Derivatives
    Publication number: 20060287532
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described, The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Application
    Filed: August 11, 2006
    Publication date: December 21, 2006
    Inventors: Laura King, Emilie Smith, Daniel Comins
  • Regiospecific synthesis of nicotine derivatives
    Patent number: 7112678
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: September 26, 2006
    Assignee: North Carolina State University
    Inventors: Laura S. King, Emilie Smith, Daniel L. Comins
  • Regioselective halogenation of nicotine and substituted nicotines
    Publication number: 20060189812
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Application
    Filed: April 28, 2006
    Publication date: August 24, 2006
    Inventors: Daniel Comins, Florence Fevrier, Emilie Smith
  • Synthesis of nicotine derivatives from nicotine
    Publication number: 20060041135
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 23, 2006
    Inventors: Daniel Comins, Emilie Smith
  • Regioselective halogenation of nicotine and substituted nicotines
    Publication number: 20050131030
    Abstract: A first aspect of the present invention is a method for of making a compound of Formula Ia or Formula Ib: wherein X is halo, by (a) metalating a precursor compound to form an organometallic intermediate, and then reacting the organometallic intermediate with a halogenating agent to produce the compound of Formula Ia or Formula Ib.
    Type: Application
    Filed: August 26, 2004
    Publication date: June 16, 2005
    Inventors: Daniel Comins, Florence Fevrier, Emilie Smith
  • Regiospecific synthesis of nicotine derivatives
    Publication number: 20050119480
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
    Type: Application
    Filed: November 17, 2003
    Publication date: June 2, 2005
    Inventors: Laura King, Emilie Smith, Daniel Comins
  • Synthesis of nicotine derivatives from nicotine
    Publication number: 20050113336
    Abstract: Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
    Type: Application
    Filed: August 25, 2004
    Publication date: May 26, 2005
    Inventors: Daniel Comins, Emilie Smith