Patents by Inventor Emilio Bunel

Emilio Bunel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SURFACE MODIFICATION OF CATALYSTIC SURFACE BY ORGANIC MOLECULES AND METAL CATIONS FOR SELECTIVE CATALYSIS
    Publication number: 20140357910
    Abstract: An article and method of manufacture of a catalyst. The article includes a nanoparticle of a noble metal based on material with a primary alkylamine layer disposed on the surface of the nanoparticle catalyst. The alkylamine layer of at least about one monolayer establishes a minimum level of selectivity for hydrogenation reactions.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 4, 2014
    Inventors: Elena Shevchenko, Soongu Kwon, Emilio Bunel, Galyna Krylova, Julius Jellinek, Aslihan Sumer, Christopher L. Marshall
  • Catalyzed process of making C-5-substituted heterocyclic inhibitors of 11?-hydroxy steroid dehydrogenase type 1
    Patent number: 7541474
    Abstract: The invention provides a process for preparing 11 ?-hydroxy steroid dehydrogenase type 1 inhibitors of formula 2 via a catalyzed reaction between a compound of formula 1 and a compound of formula R2LG in the presence of base: where R1, R2, X, Y, and LG are described in the specification. Exemplary catalysts contain palladium and one or more phosphine ligands. The process can be performed in a stereoselective manner to give enantiomerically enriched products.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: June 2, 2009
    Assignee: Amgen Inc.
    Inventors: Emilio Bunel, Anil Guram, Qingyian Liu
  • Catalyzed process of making C-5-substituted heterocyclic inhibitors of 11beta-hydroxy steroid dehydrogenase type 1
    Publication number: 20070117985
    Abstract: The invention provides a process for preparing 11 ?-hydroxy steroid dehydrogenase type 1 inhibitors of formula 2 via a catalyzed reaction between a compound of formula 1 and a compound of formula R2LG in the presence of base: where R1, R2, X, Y, and LG are described in the specification. Exemplary catalysts contain palladium and one or more phosphine ligands. The process can be performed in a stereoselective manner to give enantiomerically enriched products.
    Type: Application
    Filed: November 1, 2006
    Publication date: May 24, 2007
    Inventors: Emilio Bunel, Anil Guram, Qingyian Liu
  • Phenyl-thiophene type vitamin d receptor modulators
    Publication number: 20060287536
    Abstract: The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
    Type: Application
    Filed: May 22, 2003
    Publication date: December 21, 2006
    Inventors: Karl Dahnke, Robert Gajewski, Charles Jones, Jared Linebarger, Jianliang Lu, Tianwei Ma, Sunil Nagpal, Todd Simard, Ying Yee, Emilio Bunel, Ryan Stites
  • Process for making 5-cyanovaleric acid, adipic acid or dimethyl adipate
    Publication number: 20060258876
    Abstract: Disclosed in a process for making (1) a compound of the formula NC—CH2—CH2—CH2—CH2—CO2R?, wherein R? is H or C1 to C12 alkyl, or (2) adipic acid or (3) dimethyl adipate, using as the substrate, 3-pentenenitrile, (2) 3-pentenoic acid or methyl 3-pentenoate, respectively, by contacting the substrate with carbon monoxide and a nucleophile in the presence of a Group VIII metal, a selected ligand, and an acid promoter. The nucleophile, which (a) an alcohol or water, or (b) water or (c) methanol, respectively, in the presence of a Group VIII metal, preferably palladium, a selected phosphine ligand, and an acid promoter.
    Type: Application
    Filed: July 17, 2006
    Publication date: November 16, 2006
    Applicant: INVISTA NORTH AMERICA S.AR.L.
    Inventors: Emilio Bunel, David Clark