Patents by Inventor Emilio Hirsch

Emilio Hirsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF FIBROPROLIFERATIVE VASCULAR DISEASES
    Publication number: 20230234996
    Abstract: Fusion peptide, and pharmaceutical composition containing the same, for use in treating, preventing and/or delaying the onset of a fibroproliferative vascular disease, wherein the fusion peptide comprises: (a) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 85% similarity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and (b) a peptide having the ability to penetrate a cell.
    Type: Application
    Filed: May 24, 2021
    Publication date: July 27, 2023
    Applicant: Kither Biotech S.r.l.
    Inventors: Alessandra GHIGO, Emilio HIRSCH
  • PI3K gamma inhibitor peptide for treatment of respiratory system diseases
    Patent number: 11352400
    Abstract: Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and ii) a peptide having the ability to penetrate a cell.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: June 7, 2022
    Assignee: KITHER BIOTECH SRL
    Inventors: Emilio Hirsch, Alessandra Ghigo
  • NOVEL PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF RESPIRATORY SYSTEM DISEASES
    Publication number: 20200317740
    Abstract: Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and ii) a peptide having the ability to penetrate a cell.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 8, 2020
    Inventors: Emilio HIRSCH, Alessandra GHIGO
  • PI3K? inhibitor peptide for treatment of respiratory system diseases
    Patent number: 10730921
    Abstract: Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and ii) a peptide having the ability to penetrate a cell.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: August 4, 2020
    Assignee: KITHER BIOTECH S.R.L.
    Inventors: Emilio Hirsch, Alessandra Ghigo
  • NOVEL PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF RESPIRATORY SYSTEM DISEASES
    Publication number: 20190367571
    Abstract: Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and ii) a peptide having the ability to penetrate a cell.
    Type: Application
    Filed: August 13, 2019
    Publication date: December 5, 2019
    Inventors: EMILIO HIRSCH, Alessandra Ghigo
  • PI3K gamma inhibitor peptide for treatment of respiratory system diseases
    Patent number: 10421794
    Abstract: Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and ii) a peptide having the ability to penetrate a cell.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: September 24, 2019
    Assignee: KITHER BIOTECH SRL
    Inventors: Emilio Hirsch, Alessandra Ghigo
  • NOVEL PI3K GAMMA INHIBITOR PEPTIDE FOR TREATMENT OF RESPIRATORY SYSTEM DISEASES
    Publication number: 20180086798
    Abstract: Fusion peptide comprising: i) an amino acid sequence as defined in SEQ ID No.: 1 or a related homolog having at least 90% identity with SEQ ID No.: 1 and having the ability of the sequence SEQ ID No.: 1 to inhibit the kinase-independent function of PI3K?, and ii) a peptide having the ability to penetrate a cell.
    Type: Application
    Filed: December 22, 2015
    Publication date: March 29, 2018
    Inventors: Emilio HIRSCH, Alessandra GHIGO
  • Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
    Patent number: 8841288
    Abstract: Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 23, 2014
    Assignees: Universtà Degli Studi di Torino, Università Degli Studi del Piemonte Orientale “Amedeo Avogadro”
    Inventors: Giovanni Sorba, Gian Cesare Tron, Ubaldina Galli, Alberto Massarotti, Emilio Hirsch, Elisa Ciraolo, Tracey Pirali
  • QUINOLIN-4 (1H) -ONE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASES
    Publication number: 20130245005
    Abstract: Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity.
    Type: Application
    Filed: November 28, 2011
    Publication date: September 19, 2013
    Applicants: UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO", UNIVERSITA DEGLI STUDI DI TORINO
    Inventors: Giovanni Sorba, Gian Cesare Tron, Ubaldina Galli, Alberto Massarotti, Emilio Hirsch, Elisa Ciraolo, Tracey Pirali
  • Regulation of expression of PI3K? protein in tumors
    Patent number: 8105796
    Abstract: We describe the use of PI3K? protein and/or its encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers, as well as a method for the diagnosis of malignant cell growth comprising the measuring the expression of PI3K?. We also describe non-human transgenic animals as models for studying human pathologies, preferably breast cancer, being transgenic for having altered PI3K? and Neu-T expression.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: January 31, 2012
    Assignee: Universita' Degli Studi di Torino
    Inventors: Emilio Hirsch, Guido Forni, Claudia Curcio, Elisa Ciraolo
  • REGULATION OF EXPRESSION OF PI3KBETA PROTEIN IN TUMORS
    Publication number: 20100192240
    Abstract: The present invention concerns the use of PI3K? protein and/or encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers. The present invention also concerns a method for the diagnosis of malignant cell growth comprising the measuring the expression of PI3K? gene. The invention concerns also non-human transgenic animals as model study for human pathologies, preferably breast cancer, being transgenic for having altered PI3K? and Neu-T expression.
    Type: Application
    Filed: February 12, 2008
    Publication date: July 29, 2010
    Inventors: Emilio Hirsch, Guido Forni, Claudia Curcio, Elisa Ciraolo