Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Functional, brain region-specific neural spheroids comprising neuronal cells and optionally glial cells at varying ratios are disclosed, as are methods of making such spheroids and methods for their use, such as for modeling particular brain regions that may be implicated in diseases, or for observing drug effects.

Abstract: A system for maintaining accurate health data and for providing rewards to data market participants. A marketplace platform based on Blockchain technology leverages smart contracts to provide rewards to sellers of data assets that provide corrections or updates to medical data, such as provider demographics. A URL API is provided to a buyer of the data with an encrypted password that is used to access the data from the URL API.

Abstract: A turbomachine component is provided. The turbomachine component formed from an additive manufacturing system. The additive manufacturing system defines an axial build direction, a radial direction, and a circumferential direction. The turbomachine component includes an exterior portion. The exterior portion includes a first end wall, a second end wall, and an outer band extending axially between the first end wall and the second end wall. The turbomachine component further includes an interior portion disposed within the exterior portion. The interior portion includes a self-breaking inner band extending axially between the first end wall and the second end wall. The self-breaking inner band includes a plurality of teeth disposed between the first end wall and the second end wall.

Abstract: Disclosed herein are methods, systems and GUIs for providing situational awareness about emergency incidents to emergency service providers (ESPs), for example, between different Public Safety Answering Points. In particular, the use of data indicators, notifications and banners can be used to provide a GUI rich in situational awareness for efficient emergency response.

Abstract: A new issue management (NIMS) platform configured to track and report on New Issue data and generate visual elements, alerts and reports for interface applications. The NIMS platform provides a data capture and normalization solution. The NIMS platform can streamline data capture and dissemination processes and procedures by reducing duplicative data entry and manual input. The NIMS platform can improve data consistency by establishing automated systems across various lines of business for an organization. The NIMS platform can implement data capture, remediation and migration of current and historical data.

Abstract: A toner container for use in an image forming device according to one example embodiment includes a body having a reservoir for holding toner. The toner container includes an electrical connector having an electrical contact for contacting a corresponding electrical contact in the image forming device when the toner container is installed in the image forming device. The electrical connector is positioned in one of a plurality of predetermined positions relative to the body corresponding to at least one of a toner color and a toner type of the toner container for limiting installation of the toner container to one of a plurality of toner container receptacles in the image forming device corresponding to at least one of the toner color and the toner type of the toner container.

Abstract: A toner container according to one example embodiment includes a plurality of electrical contacts for contacting corresponding electrical contacts in an image forming device when the toner container is installed in the image forming device. The electrical contacts of the toner container are accessible from below at the bottom of the body by the corresponding electrical contacts in the image forming device when the toner container is installed in the image forming device. The electrical contacts of the toner container are spaced from each other along a horizontal dimension that is orthogonal to a vertical dimension of the toner container. A nominal position of the horizontal dimension along which the electrical contacts are spaced from each other is angled relative to a front-to-rear dimension of the toner container and a side-to-side dimension of the toner container.

Abstract: A test optical disk and a manufacturing method thereof are provided, comprising at least one bit value at a default position in an original image data, forming an error bit by reverting the captured bit value, storing error data consisted of error bits back to the default position in the original image file to form a test image data, and writing the test image file onto an optical disk. Furthermore, the steps of setting an error amount, selecting an error mode, and selecting a distribution method are further used to determine a length of the error data and the distribution of the default position thereof. This way, not only optical disks simulating various error statuses can be produced, but also the error statuses have reproducibility to help developers to improve the optical disk technology.

Abstract: A test optical disk and a manufacturing method thereof are provided, comprising at least one bit value at a default position in an original image data, forming an error bit by reverting the captured bit value, storing error data consisted of error bits back to the default position in the original image file to form a test image data, and writing the test image file onto an optical disk. Furthermore, the steps of setting an error amount, selecting an error mode, and selecting a distribution method are further used to determine a length of the error data and the distribution of the default position thereof This way, not only optical disks simulating various error statuses can be produced, but also the error statuses have reproducibility to help developers to improve the optical disk technology.

Abstract: The present invention provides an audio/video recording system with a play list pre-editor and method thereof. The audio/video recording system with a play list pre-editor comprises a pre-editor module for editing a record list comprising parameters of audio/video programs, wherein said audio/video programs are classified into a plurality of play lists according to play list identifications in said parameters, and a record module for recording said audio/video programs according to said parameters. Furthermore, said play lists are created for classifying said audio/video programs, and each of said play lists is used for presenting a portion of said audio/video programs with an identical play list identification.