Patents by Inventor Emily M. Stocking

Emily M. Stocking has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISUBSTITUTED OCTAHYDROPYRROLO[3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS
    Publication number: 20240109901
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: June 2, 2023
    Publication date: April 4, 2024
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
    Publication number: 20240043395
    Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 8, 2024
    Inventors: Srinivasa Reddy NATALA, Wolfgang J. WRASIDLO, Emily M. STOCKING
  • SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF
    Publication number: 20230391734
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: June 5, 2023
    Publication date: December 7, 2023
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA, Diana Luz PRICE
  • TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS
    Publication number: 20230265086
    Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Application
    Filed: November 7, 2022
    Publication date: August 24, 2023
    Applicant: Neuropore Therapies, Inc.
    Inventors: Emily M. STOCKING, Wolfgang J. WRASIDLO
  • Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
    Patent number: 11708338
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: July 25, 2023
    Assignee: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. Wrasidlo, Emily M. Stocking, Srinivasa Reddy Natala, Diana Luz Price
  • Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Patent number: 11667644
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: June 6, 2023
    Assignee: Janssen Pharmaceutica NV
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
    Patent number: 11492348
    Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: November 8, 2022
    Assignee: Neuropore Therapies, Inc.
    Inventors: Emily M. Stocking, Wolfgang J. Wrasidlo
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
    Publication number: 20220298155
    Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Application
    Filed: February 10, 2022
    Publication date: September 22, 2022
    Applicant: Neuropore Therapies, Inc.
    Inventors: Srinivasa Reddy NATALA, Wolfgang J. WRASIDLO, Emily M. STOCKING
  • Compounds and compositions as modulators of TLR signaling
    Patent number: 11299487
    Abstract: The present disclosure relates to substituted aryl and heteroaryl compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: April 12, 2022
    Assignee: Neuropore Therapies, Inc.
    Inventors: Srinivasa Reddy Natala, Wolfgang J. Wrasidlo, Emily M. Stocking
  • Morpholine derivates as inhibitors of Vps34
    Patent number: 11236079
    Abstract: The present disclosure relates to thiazole- or diathiazole-substituted aryl and heteroaryl compounds (I), pharmaceutical compositions containing them, and methods of using them, including treatment of disorders or disease related to regulation of the Vps34/PI3K III signaling pathway.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 1, 2022
    Assignee: Neuropore Therapies, Inc.
    Inventors: Emily M. Stocking, Wolfgang J. Wrasidlo
  • Disubstituted Octahydropyrrolo[3,4-c]Pyrroles As Orexin Receptor Modulators
    Publication number: 20210347781
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: July 9, 2021
    Publication date: November 11, 2021
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF
    Publication number: 20210300881
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: April 6, 2021
    Publication date: September 30, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA, Diana Luz PRICE
  • METHOD OF TREATING A CONDITION ASSOCIATED WITH NEURODEGENERATION USING INHIBITORS OF OAT3
    Publication number: 20210290597
    Abstract: The present disclosure relates to therapeutic agents that may be useful intreatment and prophylaxis of neurodegenerative disorders and/or neural inflammation.
    Type: Application
    Filed: June 20, 2019
    Publication date: September 23, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Douglas W. BONHAUS, Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA
  • Heteroaryl amides as inhibitors of protein aggregation
    Patent number: 11078196
    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 3, 2021
    Assignee: UCB Biophama SRL
    Inventors: Wolfgang Wrasidlo, Emily M. Stocking
  • Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators
    Patent number: 11059828
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: July 13, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS
    Publication number: 20210163462
    Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Application
    Filed: April 9, 2019
    Publication date: June 3, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Emily M. STOCKING, Wolfgang J. WRASIDLO
  • MORPHOLINE DERIVATES AS INHIBITORS OF VPS34
    Publication number: 20210163467
    Abstract: The present disclosure relates to thiazole- or diathiazole-substituted aryl and heteroaryl compounds (I), pharmaceutical compositions containing them, and methods of using them, including treatment of disorders or disease related to regulation of the Vps34/PI3K III signaling pathway.
    Type: Application
    Filed: April 9, 2019
    Publication date: June 3, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Emily M. STOCKING, Wolfgang J. WRASIDLO
  • Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
    Patent number: 11008294
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: May 18, 2021
    Assignee: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. Wrasidlo, Emily M. Stocking, Srinivasa Reddy Natala, Diana Luz Price
  • Bis-heteroaryl derivatives as modulators of protein aggregation
    Patent number: 10975066
    Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: April 13, 2021
    Assignee: UCB Biopharma SRL
    Inventors: Wolfgang Wrasidlo, Emily M. Stocking, Adrian Hall, Malcolm Maccoss
  • Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Patent number: RE48841
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: December 7, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode-Johnson, Emily M. Stocking, Devin M. Swanson