Patents by Inventor Emily P. THI

Emily P. THI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED CONJUGATES COMPRISING MODIFIED SIRNA
    Publication number: 20240052349
    Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, an siRNA, and optional linking groups. The conjugates are useful to target siRNA.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 15, 2024
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Owen M. DALY, Amy C. H. LEE, Michael J. SOFIA, Emily P. THI
  • TARGETED COMPOSITIONS
    Publication number: 20230110295
    Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
    Type: Application
    Filed: June 30, 2022
    Publication date: April 13, 2023
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: James HEYES, Richard J. HOLLAND, Adam JUDGE, Amy C. H. LEE, Alan D. MARTIN, Nicholas Michael SNEAD, Emily P. THI, Mark WOOD, Xin YE
  • Targeted compositions
    Patent number: 11427823
    Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: August 30, 2022
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: James Heyes, Richard J. Holland, Adam Judge, Amy C. H. Lee, Alan D. Martin, Nicholas Michael Snead, Emily P. Thi, Mark Wood, Xin Ye
  • THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING HEPATITIS B
    Publication number: 20220265817
    Abstract: The invention provides therapeutic combinations and therapeutic methods that are useful for treating hepatitis B.
    Type: Application
    Filed: May 31, 2018
    Publication date: August 25, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Amy C. H. LEE, Emily P. THI
  • THERAPEUTIC METHODS FOR TREATING HEPATITIS B
    Publication number: 20220168430
    Abstract: The invention provides therapeutic combinations and therapeutic methods that are useful for treating Hepatitis B and Hepatitis D.
    Type: Application
    Filed: March 19, 2020
    Publication date: June 2, 2022
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Andrzej ARDZINSKI, Andrea CUCONATI, Amy C. H. LEE, Nagraj MANI, Cornelis A. RIJNBRAND, Michael J. SOFIA, Emily P. THI
  • TARGETED COMPOSITIONS
    Publication number: 20200407724
    Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
    Type: Application
    Filed: April 10, 2018
    Publication date: December 31, 2020
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: James HEYES, Richard J. HOLLAND, Adam JUDGE, Amy C. H. LEE, Alan D. MARTIN, Nicholas Michael SNEAD, Emily P. THI, Mark WOOD, Xin YE
  • Compositions and methods for silencing hepatitis B virus gene expression
    Patent number: 10415037
    Abstract: The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: September 17, 2019
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Jennifer L. Cross, Ammen P. Dhillon, Amy C. H. Lee, Ian MacLachlan, Nicholas M. Snead, Emily P. Thi
  • COMPOSITIONS AND METHODS FOR SILENCING HEPATITIS B VIRUS GENE EXPRESSION
    Publication number: 20180208932
    Abstract: The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).
    Type: Application
    Filed: July 28, 2016
    Publication date: July 26, 2018
    Applicant: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Amy C. H. LEE, Nicholas Michael SNEAD, Emily P. THI
  • COMPOSITIONS AND METHODS FOR SILENCING HEPATITIS B VIRUS GENE EXPRESSION
    Publication number: 20180016583
    Abstract: The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).
    Type: Application
    Filed: October 1, 2015
    Publication date: January 18, 2018
    Applicant: PROTIVA BIOTHERAPEUTICS, INC.
    Inventors: Jennifer L. CROSS, Ammen P. DHILLON, Amy C. H. LEE, Ian MACLACHLAN, Nicholas M. SNEAD, Emily P. THI