Abstract: Provided herein are methods of treatment of AML comprising administering 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof in a combination therapy.

Abstract: Provided herein are formulations and methods of use of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Abstract: A structured surfactant system with a very high degree of clarity. The system comprises water and a mixture of at least one surfactant having a HLB (Hydrophilic Lipophilic Balance) value of less than 10, and at least one surfactant having an HLB value of 10 or greater. The structured surfactant system forms multilamellar vesicles and has suspending properties without added electrolytes, carbohydrates, or polymeric thickeners. This makes the structured surfactant system particularly useful in personal care compositions.

Abstract: The present invention relates to an aqueous conditioning serum. Despite the prior art there remains the need for improved serum conditioners. Accordingly, the present invention provides a visually clear aqueous conditioning serum for the hair comprising: 50 to 95% wt. water, 0.1 to 8% wt. silicone microemulsion, 5 to 15% wt. copolymer of ethylene glycol and propylene glycol according to one of the following formula: HO(CH2CH2O)x(CH(CH3)CH2O)y(CH2CH2O)z H (I) HO(CH(CH3)CH2O)x(CHCH2O)y(CH2(CH3)CH2O)z H (II) with the mean value of y in the range from 10 to 60 and the values of x and z both in the range from 1 to 150, 0.5 to 1.5% wt. thickener. The composition according to the invention conditions the hair without depositing too much silicone. Accordingly, it reduces the risk of applying too much and leaving the hair feeling lank and greasy.

Abstract: A structured surfactant system with a very high degree of clarity. The system comprises water and a mixture of at least one surfactant having a HLB (Hydrophilic Lipophilic Balance) value of less than 10, and at least one surfactant having an HLB value of 10 or greater. The structured surfactant system forms multilamellar vesicles and has suspending properties without added electrolytes, carbohydrates, or polymeric thickeners. This makes the structured surfactant system particularly useful in personal care compositions.

Abstract: The present invention relates to an aqueous conditioning serum. Despite the prior art there remains the need for improved serum conditioners. Accordingly, the present invention provides a visually clear aqueous conditioning serum for the hair comprising: 50 to 95% wt. water, 0.1 to 8% wt. silicone microemulsion, 5 to 15% wt. copolymer of ethylene glycol and propylene glycol according to one of the following formulae: HO(CH2CH2O)x(CH(CH3)CH2O)y(CH2CH2O)zH (I) HO(CH(CH3)CH2O)x(CHCH2O)y(CH2(CH3)CH2O)zH (II) with the mean value of y in the range from 10 to 60 and the values of x and z both in the range from 1 to 150, 0.5 to 1.5% wt. thickener. The composition according to the invention conditions the hair without depositing too much silicone. Accordingly, it reduces the risk of applying too much and leaving the hair feeling lank and greasy.