Patents by Inventor Emily R. Rolfes

Emily R. Rolfes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190269698
    Abstract: Embodiments of the present invention are directed to a plurality of substantially spherical microspheres comprising at least one API substantially dispersed in at least one polymer and a lyoprotectant on an outside surface of the plurality of substantially spherical microspheres, wherein the plurality of substantially spherical microspheres have a D99[num] particle diameter of less than about 10 m; a D90[num] circularity value of from about 0.8 to about 1.0; and comprise API in a weight of about 20 to about 40 wt. % of the polymer. Other embodiments relate to injectable compositions comprising such microspheres and methods of treating a number of conditions by administering such injectable compositions to a subject.
    Type: Application
    Filed: October 28, 2016
    Publication date: September 5, 2019
    Inventors: Jeffrey Missling, Emily R. Rolfes Meyering, Henry Meyer, Celeste Ondich
  • Patent number: 9987115
    Abstract: Various embodiments of an implant devices and systems are provided. The implant devices can include a mesh or implant encapsulated or otherwise coated, in whole or in part, with a film or coating. The coating or film can include methylcellulose or ethylcellulose to provide tissue regeneration as a hydrogel, while also providing a stiff polymer film when dry.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: June 5, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Benjamin Y. Arcand, James A. Kazmierkoski, Dean W. Hacker, Emily R. Rolfes Meyering
  • Patent number: 9949811
    Abstract: Various embodiments of a mesh or implant system are provided for treating pelvic conditions such as incontinence, vaginal prolapsed, and other conditions caused by muscle and ligament weakness. Embodiments of the implants can include a material, substrate, configuration or coating adapted to provide immediate or timed release of various therapeutic agents or drugs to treat the surrounding tissue.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: April 24, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: John R. Frigstad, Thomas Q. Dinh, Emily R. Rolfes-Meyering
  • Patent number: 9649405
    Abstract: Compositions, systems, and methods for the treatment of pelvic tissue conditions that include use of a silk fibroin-containing hydrogel composition are disclosed. The composition may include a water-soluble fibroin and a water-soluble crosslinkable polymer that can be used as a pre-formed hydrogel, and/or delivered to a pelvic tissue site and crosslinked in situ to form a hydrogel. The composition may promote tissue closure, such as vaginal wound or fistula closure; and/or enhance attachment or anchoring of a pelvic implant to a pelvic tissue. The composition may be a hydrogel that is delivered to a pelvic tissue site, formed at the site in situ, and/or associated with a portion of the implant (e.g., a mesh implant) via a tether or implant extension portion, thereby providing improved immobilization of the implant. Systems or kits that include the composition and/or a delivery needle or insertion tool are also described.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: May 16, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Emily R. Rolfes Meyering, Benjamin Y. Arcand
  • Patent number: 9539079
    Abstract: Described are pelvic implants, systems including the implant and a delivery tool, and methods for the treatment of incontinence or prolapse. The implant has an expansion member associated with a support portion and a tensioning member along an extension portion of the implant. Systems and methods for treating incontinence or prolapse that include a composition having non-absorbable fibers of different sizes that can be applied to and set on an implant are also provided.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: January 10, 2017
    Inventor: Emily R. Rolfes Meyering
  • Publication number: 20150314035
    Abstract: The disclosure provides compositions, systems, and methods for the treatment of pelvic tissue conditions that include use of a silk fibroin-containing hydrogel composition. The composition includes water-soluble fibroin and a water-soluble crosslinkable polymer. The composition can be used as a pre-formed hydrogel or can be delivered to a pelvic tissue site and crosslinked in situ to form a hydrogel. The composition can be used to promote tissue closure, such as vaginal wound or fistula closure. The composition can also be used to enhance attachment or anchoring of a pelvic implant to a pelvic tissue. A hydrogel delivered to a pelvic tissue site, or formed at the site in situ, is associated with a portion of the implant (e.g., a mesh implant) via a tether or implant extension portion, thereby providing improved immobilization of the implant. Systems or kits that include the composition and a delivery needle or insertion tool are also described.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 5, 2015
    Applicant: AMS Research Corporation
    Inventors: Emily R. Rolfes Meyering, Benjamin Y. Arcand
  • Patent number: 8999377
    Abstract: Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-?(1?4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: April 7, 2015
    Assignee: Surmodics, Inc.
    Inventors: Emily R. Rolfes, Pamela J. Reed
  • Publication number: 20150018602
    Abstract: Described are pelvic implants, systems including the implant and a delivery tool, and methods for the treatment of incontinence or prolapse. The implant has an expansion member associated with a support portion and a tensioning member along an extension portion of the implant. Systems and methods for treating incontinence or prolapse that include a composition having non-absorbable fibers of different sizes that can be applied to and set on an implant are also provided.
    Type: Application
    Filed: August 3, 2012
    Publication date: January 15, 2015
    Applicant: AMS Research Corporation
    Inventor: Emily R. Rolfes Meyering
  • Patent number: 8932694
    Abstract: The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 13, 2015
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • Patent number: 8927000
    Abstract: The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: January 6, 2015
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Emily R. Rolfes Meyering
  • Patent number: 8790701
    Abstract: The present invention provides biocompatible, biodegradable matrices formed from poly-?(1?4)glucopyranose and reactive hydrazide groups. The matrices can be used for various applications in the body, including drug delivery and cell therapy.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: July 29, 2014
    Assignee: SurModics, Inc.
    Inventors: Emily R. Rolfes, Jeff J. Ross, Joseph S. McGonigle, Gary W. Opperman, Pamela J. Reed
  • Patent number: 8722076
    Abstract: The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: May 13, 2014
    Assignee: SurModics, Inc.
    Inventors: Emily R. Rolfes Meyering, Aron B. Anderson
  • Publication number: 20140088343
    Abstract: Various embodiments of an implant devices and systems are provided. The implant devices can include a mesh or implant encapsulated or otherwise coated, in whole or in part, with a film or coating. The coating or film can include methylcellulose or ethylcellulose to provide tissue regeneration as a hydrogel, while also providing a stiff polymer film when dry.
    Type: Application
    Filed: March 30, 2012
    Publication date: March 27, 2014
    Applicant: AMS RESEARCH CORPORATION
    Inventors: Benjamin Y. Arcand, James A. Kazmierkoski, Dean W. Hacker, Emily R. Rolfes Meyering
  • Patent number: 8586731
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 19, 2013
    Assignee: Surmodics, Inc.
    Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Pamela J. Reed
  • Patent number: 8568760
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 29, 2013
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • Publication number: 20120165786
    Abstract: The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
    Type: Application
    Filed: June 30, 2011
    Publication date: June 28, 2012
    Inventors: Ralph A. Chappa, Emily R. Rolfes Meyering
  • Publication number: 20120114589
    Abstract: The invention provides biodegradable polymeric hydrogel matrices having excellent durability and swellability. The matrices are formed from a combination of poly-?(1?4)glucopyranose macromer and a biocompatible biostable hydrophilic macromer. The matrices can be used in association with a medical device or alone. In some methods the polymeric matrix is placed or formed at a target site in which the matrix swells and occludes the target area, and is able to be degraded at the target site after period of time.
    Type: Application
    Filed: October 22, 2009
    Publication date: May 10, 2012
    Inventors: Emily R. Rolfes-Meyering, Stephen Chudzik, Pamela J. Reed
  • Publication number: 20120082713
    Abstract: The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.
    Type: Application
    Filed: September 29, 2011
    Publication date: April 5, 2012
    Inventors: Emily R. Rolfes Meyering, Aron B. Anderson
  • Publication number: 20120052107
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Application
    Filed: December 30, 2010
    Publication date: March 1, 2012
    Inventor: Emily R. Rolfes Meyering
  • Publication number: 20110318575
    Abstract: The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.
    Type: Application
    Filed: June 29, 2011
    Publication date: December 29, 2011
    Inventor: Emily R. Rolfes Meyering