Patents by Inventor Emily Ruff

Emily Ruff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein kinase allostery sensor and methods of making and using same
    Patent number: 11099177
    Abstract: A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: August 24, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Nicholas Mark Levinson, Emily Ruff, Joseph M. Muretta, David D. Thomas, Eric Lake
  • PROTEIN KINASE ALLOSTERY SENSOR AND METHODS OF MAKING AND USING SAME
    Publication number: 20190361014
    Abstract: A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening.
    Type: Application
    Filed: September 8, 2017
    Publication date: November 28, 2019
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Nicholas Mark Levinson, Emily Ruff, Joseph M. Muretta, David D. Thomas, Eric Lake