Patents by Inventor Emily Severance

Emily Severance has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding functional splice variants of the ?7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins
    Patent number: 7563595
    Abstract: The present invention concerns a novel ?7 nicotinic receptor subunit isoform, ?7-2. The ?7-2 isoform contributes to novel acetylcholine receptors (AChRs) with pharmacological and biophysical properties distinct from those of wild-type ?7-1-nAChRs and closely resembling those of ?7-nAChRs found in intrinsic cardiac neurons and Type II ?7-nAChRs of superior cervical ganglion neurons. Polynucleotides encoding the ?7-2 isoform, vectors and genetically modified cells containing such polynucleotides are also provided. In addition, methods are provided for producing the ?7-2 isoform as are methods of using such isoforms for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: July 21, 2009
    Assignee: University of South Florida
    Inventors: Javier Cuevas, Emily Severance
  • Functional splice variant of the alpha7 nicotinic acetylcholine receptor subunit and uses thereof
    Publication number: 20040152160
    Abstract: The present invention concerns a novel &agr;7 nicotinic receptor subunit isoform, &agr;7-2. The &agr;7-2 isoform contributes to novel acetylcholine receptors (AChRs) with pharmacological and biophysical properties distinct from those of wild-type &agr;7-1-nAChRs and closely resembling those of (&agr;7-nAChRs found in intrinsic cardiac neurons and Type II &agr;7-nAChRs of superior cervical ganglion neurons. Polynucleotides encoding the &agr;7-2 isoform, vectors and genetically modified cells containing such polynucleotides are also provided. In addition, methods are provided for producing the &agr;7-2 isoform as are methods of using such isoforms for screening compounds for activity at the nAChR.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 5, 2004
    Inventors: Javier Cuevas, Emily Severance