Abstract: A optical system and imaging device provide simultaneous or sequential optogenetic stimulation of different locations within a biological sample and fluorescence imaging of the locations. The systems include an illumination array with multiple electrically addressable elements that select a spatial pattern of illumination, an optical fiber bundle with fibers coupled between the array element and target locations at the sample, a fluorescence illumination source, and an imaging system for measuring fluorescence returning from the target locations. The optical imaging devices include a housing and a sample connector configured for receiving a first optical fiber bundle connection including multiple optical fibers. The sample connector has an indexing feature to maintain a fixed relationship between the fibers and internal optical paths of the device.

Abstract: Processing of incoherent electromagnetic radiation is described, said incoming incoherent electromagnetic radiation comprising radiation in a first wavelength interval. An arrangement comprises a focusing arrangement for focusing the incoming incoherent electromagnetic radiation, a first cavity configured to comprise an intra cavity laser beam, a nonlinear crystal arranged in the first cavity such that it is capable of receiving the focused incoherent electromagnetic radiation and, in dependence on the spatial overlap between the focused incoherent electromagnetic radiation and the intra-cavity laser beam, by interaction with the intra-cavity laser beam provide processed electromagnetic radiation, said processed electromagnetic radiation comprising radiation in a second wavelength interval. In other words, such an arrangement is capable of enabling imaging, e.g.

Abstract: Processing of incoherent electromagnetic radiation is described, said incoming incoherent electromagnetic radiation comprising radiation in a first wavelength interval. An arrangement comprises a focusing arrangement for focusing the incoming incoherent electromagnetic radiation, a first cavity configured to comprise an intra cavity laser beam, a nonlinear crystal arranged in the first cavity such that it is capable of receiving the focused incoherent electromagnetic radiation and, in dependence on the spatial overlap between the focused incoherent electromagnetic radiation and the intra-cavity laser beam, by interaction with the intra-cavity laser beam provide processed electromagnetic radiation, said processed electromagnetic radiation comprising radiation in a second wavelength interval. In other words, such an arrangement is capable of enabling imaging, e.g.