Abstract: The present disclosure relates to a system, a method, and a computer program product for neuro-ophthalmic risk assessment(s) of a user. The method includes receiving facial image(s) of the user from a user device. The method further includes determining parametric value(s) associated with at least one facial feature of the user, based on the facial image(s) using neuro-ophthalmic test(s). Furthermore, the method includes determining a measure of risk for the user based on the parametric value(s) using Machine Learning (ML) models. The measure of risk indicates a level of neuro-ophthalmic risk associated with the user.

Abstract: There is provided processes for the preparation of various compounds, including compounds of formulae I, IV and VII, or salts and/or solvates thereof, which compounds are useful intermediates in the synthesis of certain oxabispidines having antiarrhythmic activity, such as compounds of formula XI wherein R1?, R15?, R16?, R18? and D have meanings given in the description.

Abstract: The present invention concerns a process for the preparation of an N-(4-piperidinyl)-N-ethyl-phenylacetamide of formula (I); wherein R1 and R2 are independently selected from the group comprising: hydrogen, halogen, C1-4 alkyl, C1-4alkoxy, cyano and S(O)2(C1-4 alkyl).

Abstract: The present invention concerns a process for the preparation of an N-(4-piperidinyl)-N-ethyl-phenylacetamide of formula (I); wherein R1 and R2 are independently selected from the group comprising: hydrogen, halogen, C1-4 alkyl, C1-4alkoxy, cyano and S(O)2(C1-4 alkyl).