Patents by Inventor Emma Dave
Emma Dave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230242677Abstract: Multi-specific Antibodies The present disclosure relates to a multi-specific antibody comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-(CH2)-(CH3)-(X)-(V1); and b) a polypeptide chain of formula (II): (V3)-(Z) -VL-CL-(Y)-(V2) wherein the polypeptide chain of formula (II) comprises at least one dsscFv, dsFv, scFv, VH or VHH, and wherein the polypeptide chain of formula (I) comprises a protein A binding domain and wherein the polypeptide chain of formula (II) does not bind protein A. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. The disclosure also provides pharmaceutical formulations comprising same, for example for use in treatment. There is also provided a method of expressing a multi-specific antibody of the present disclosure from a host cell.Type: ApplicationFiled: December 18, 2020Publication date: August 3, 2023Inventors: Emily Mary Cairistine Barry, Emma Dave, Sam Philip Heywood
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Publication number: 20230087378Abstract: The present invention relates to a multi-specific antibody having specificity for human IL-13, human IL-17A and/or human IL-17F. The invention further relates to methods for producing the multi-specific antibody and to its therapeutic use for the treatment of atopic dermatitis and other diseases.Type: ApplicationFiled: December 18, 2020Publication date: March 23, 2023Inventors: Adnan Rahman Khan, Sam Philip Heywood, David Paul Humphreys, Daniel John Lightwood, Emma Dave, Emily Mary Cairistine Barry, Sarah Jayne Stanyon
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Patent number: 11427650Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.Type: GrantFiled: January 21, 2019Date of Patent: August 30, 2022Assignee: UCB BIOPHARMA SRLInventors: David Paul Humphreys, Emma Dave, Laura Griffin, Sam Philip Heywood
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Publication number: 20220267476Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.Type: ApplicationFiled: May 2, 2022Publication date: August 25, 2022Inventors: Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 11401349Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, nindependently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V1 and V2, in particular where a disulphide bond is present.Type: GrantFiled: September 17, 2019Date of Patent: August 2, 2022Assignee: UCB Biopharma SRLInventors: Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 11345760Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.Type: GrantFiled: June 25, 2015Date of Patent: May 31, 2022Assignee: UCB BIOPHARMA SRLInventors: Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 11091542Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: December 14, 2016Date of Patent: August 17, 2021Assignee: UCB BIOPHARMA SRLInventors: Ralph Adams, Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys, Diane Marshall, Daniel John Lightwood
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Publication number: 20200291104Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: December 14, 2016Publication date: September 17, 2020Inventors: Ralph Adams, Pallavi Bhatta, Emma Dave, Sam Philip Heywood, Dave Paul Humphreys, Diane Marshall, Daniel John Lightwood
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Publication number: 20200277366Abstract: The invention relates to multi-specific antibody molecules having specificity for TNF alpha, IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: ApplicationFiled: December 14, 2016Publication date: September 3, 2020Applicant: UCB Biopharma SPRLInventors: Ralph ADAMS, Pallavi BHATTA, Emma DAVE, Sam Philip HEYWOOD, David Taul HUMPHERYS, Diane MARSHALL, Stevan Graham SHAW, Daniel John LIGHTWOOD
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Publication number: 20200055959Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, nindependently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V1 and V2, in particular where a disulphide bond is present.Type: ApplicationFiled: September 17, 2019Publication date: February 20, 2020Inventors: Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 10457748Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III): V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present.Type: GrantFiled: December 20, 2013Date of Patent: October 29, 2019Assignee: UCB BIOPHARMA SPRLInventors: Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Patent number: 10421816Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.Type: GrantFiled: May 26, 2016Date of Patent: September 24, 2019Assignee: UCB BIOPHARMA SPRLInventors: Ralph Adams, Emma Dave, David Paul Humphreys
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Publication number: 20190127489Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.Type: ApplicationFiled: January 21, 2019Publication date: May 2, 2019Inventors: David Paul Humphreys, Emma Dave, Laura Griffin, Sam Philip Heywood
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Patent number: 10100130Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.Type: GrantFiled: October 24, 2017Date of Patent: October 16, 2018Assignee: UCB BIOPHARMA SPRLInventors: David Paul Humphreys, Emma Dave, Laura Griffin, Sam Philip Heywood
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Publication number: 20180127498Abstract: The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.Type: ApplicationFiled: May 9, 2016Publication date: May 10, 2018Applicant: UCB Biopharma SPRLInventors: Pallavi BHATTA, Emma DAVE, Sam Philip HEYWOOD, David Paul HUMPHREYS, Bryan John SMITH
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Publication number: 20180118853Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.Type: ApplicationFiled: October 24, 2017Publication date: May 3, 2018Inventors: David Paul Humphreys, Emma Dave, Laura Griffin, Sam Philip Heywood
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Patent number: 9828438Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab? fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.Type: GrantFiled: July 6, 2016Date of Patent: November 28, 2017Assignee: UCB Pharma S.A.Inventors: David Paul Humphreys, Emma Dave, Laura Griffin, Sam Philip Heywood
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Publication number: 20170204200Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.Type: ApplicationFiled: June 25, 2015Publication date: July 20, 2017Inventors: Pallavi BHATTA, Emma DAVE, Sam Philip HEYWOOD, David Paul HUMPHREYS
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Publication number: 20170198062Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-CH2-CH3-X-(V1)p; and b) a polypeptide chain of formula (II): VL-CL-Y-(V2)q and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multi-specific antibody molecule of the present disclosure from a host cell.Type: ApplicationFiled: June 25, 2015Publication date: July 13, 2017Applicant: UCB BIOPHARM SPRLInventors: Pallavi Bhatta, Emma Dave, Sam Philip Heywood, David Paul Humphreys
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Publication number: 20160333105Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.Type: ApplicationFiled: May 26, 2016Publication date: November 17, 2016Inventors: Ralph Adams, Emma Dave, David Paul Humphreys