Abstract: A needle guide for an angled ultrasound probe having a port tower with a plurality of needle ports aligned with an angled ultrasonic imaging plane. The needle ports in a port tower are aligned at the offset angle of the angled ultrasound probe and can support and guide a needle at the offset angle. Adjustment of the port tower along the transducer axis of the angled ultrasound probe maintains the alignment of the needle ports relative to the ultrasonic imaging plane and provides adjustment to accommodate differently sized patients. A method is also provided to securely align a needle with an angled ultrasonic imaging plane with an angled ultrasound probe such that the needle can accurately transect the ultrasound imaging plane.