Abstract: An absorbent article is disclosed. The article includes a topsheet formed of a section of formed nonwoven web material having an ordered arrangement of zones, each zone comprising one or more attenuated regions adjacent to one or more built-up regions, wherein the attenuated regions have a first average basis weight and the built-up regions have a second average basis weight, wherein the first average basis weight is less than the second average basis weight, the difference in basis weights corresponding to disposition of the filaments according to the ordered arrangement. The attenuated region(s) may be included within a configuration of one or more channel portions on the topsheet. Alternatively or in combination, the attenuated region(s) may be included within a hinge portion extending along a wing portion of the topsheet.

Abstract: A method for generating a user interface for analyzing a patient-specific electronic medical or health record that includes a problem list includes the steps of grouping related potential problems into problem list categories, grouping a subset of the problems into clusters within the categories, mapping, using a computer, entries in the problem list with a respective description in an interface terminology, associating one or more of other medical data, e.g., medication, lab results, procedures, imaging results, past medical history or surgeries, notes, vital signs, or allergy data in the record with at least one problem, receiving a request corresponding to a problem or problem list category or to other medical data, identifying non-problem data in the record grouped in a cluster with the requested data, and modifying a user interface to display the identified data separate from other similar medical data included in the electronic medical or health record.

Abstract: Systems and methods for using temporal objects for natural language processing. One system includes an electronic processor configured to receive a set of electronic records of a patient, where each electronic record is associated with an event of the patent. The electronic processor is also configured to determine a temporal statement and an associated element, where the temporal statement and the associated element are associated with the event. The electronic processor is also configured to determine a temporal characteristic for the event based on the temporal statement and the associated element. The electronic processor is also configured to generate, based on the temporal characteristic, a temporal event entry associated with the event for a profile of the patient and enable access to the temporal event entry.

Abstract: A method for generating a user interface for analyzing a patient-specific electronic medical or health record that includes a problem list includes the steps of grouping related potential problems into problem list categories, grouping a subset of the problems into clusters within the categories, mapping, using a computer, entries in the problem list with a respective description in an interface terminology, associating one or more of other medical data, e.g., medication, lab results, procedures, imaging results, past medical history or surgeries, notes, vital signs, or allergy data in the record withdf at least one problem, receiving a request corresponding to a problem or problem list category or to other medical data, identifying non-problem data in the record grouped in a cluster with the requested data, and modifying a user interface to display the identified data separate from other similar medical data included in the electronic medical or health record.

Abstract: A method for generating a user interface for analyzing a patient-specific electronic medical or health record that includes a problem list includes the steps of grouping related potential problems into problem list categories, grouping a subset of the problems into clusters within the categories, mapping, using a computer, entries in the problem list with a respective description in an interface terminology, associating one or more of other medical data, e.g., medication, lab results, procedures, imaging results, past medical history or surgeries, notes, vital signs, or allergy data in the record with at least one problem, receiving a request corresponding to a problem or problem list category or to other medical data, identifying non-problem data in the record grouped in a cluster with the requested data, and modifying a user interface to display the identified data separate from other similar medical data included in the electronic medical or health record.

Abstract: A method for generating orders for a care plan through a problem list in an electronic medical record or an electronic health record includes the steps of mapping, using a computer, entries in a problem list with a respective concept in an interface terminology, analyzing, by a computer, each mapped entry to determine related problem list entries, grouping related entries into one or more categories, and aggregating a plurality of care plans relevant to one of the categories. Care plans may include medications and labs, and each care plan entry also may be coded with an external terminology, such as RxNorm or LOINC.

Abstract: A multi-stage pressure regulator system. The system of the present invention provides for distribution of the Joules-Thomson (J-T) cooling effect between multiple stages. In the preferred embodiment of the present invention, the pressure is first reduced by a set ratio in one or more stages followed by an adjustable pressure output stage. The present invention thereby provides a system to control pressure reduction and thus prevent condensation (and associated distortion of a vapor composition sample) of a gas due to J-T cooling effect. The system of the present invention is particularly suitable for use placement (via, for example, a probe) within the source gas supply containment vessel, pipeline or the like, so that pressure reduction occurs at or near isothermal conditions, further lessening the likelihood of J-T condensation.

Abstract: A method for the fluorescent detection of a substance, the method comprising providing particles comprising a metal or a metal oxide core, wherein one or more optionally fluorescently tagged antibodies or human specific peptide nucleic acid (PNA) oligomers for binding to a substance is/are bound, directly or indirectly, to the surface of the metal or metal oxide; contacting a substrate, which may or may not have the substance on its surface, with the particles for a time sufficient to allow the antibody/PNA oligomer to bind with the substance; removing those particles which have not bound to the substrate; if the antibodies or PNA oligomers are not fluorescently tagged, contacting the substrate with one or more fluorophores that selectively bind with the antibody and/or substance, then optionally washing the substrate to remove unbound fluorophores; and illuminating the substrate with appropriate radiation to show the fluorophores on the substrate.

Abstract: A method for the fluorescent detection of a substance, the method comprising providing particles comprising a metal or a metal oxide core, wherein one or more optionally fluorescently tagged antibodies or human specific peptide nucleic acid (PNA) oligomers for binding to a substance is/are bound, directly or indirectly, to the surface of the metal or metal oxide; contacting a substrate, which may or may not have the substance on its surface, with the particles for a time sufficient to allow the antibody/PNA oligomer to bind with the substance; removing those particles which have not bound to the substrate; if the antibodies or PNA oligomers are not fluorescently tagged, contacting the substrate with one or more fluorophores that selectively bind with the antibody and/or substance, then optionally washing the substrate to remove unbound fluorophores; and illuminating the substrate with appropriate radiation to show the fluorophores on the substrate.

Abstract: Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

Abstract: The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

Abstract: The present invention involves a garment accessory that provides unrestricted access to certain fingers of a hand while also providing a covering such that the fingers to be accessed remain purposefully covered. The garment accessory is primarily constructed of a series of spaced apart elastic rings which fit around the arm of a wearer, a series of longitudinal strips having taffeta or a decorative covering stitched thereto wherein the longitudinal strips are fastened to the elastic rings, sheaths for receiving the middle finger, thumb and pinky finger, and two slots for receiving the ring finger and forefinger. During a marriage ceremony, for example, the bride is not required to remove the garment accessory for the ring portion of the ceremony as would be required with a conventional decorative glove, thereby facilitating a more efficient and convenient ceremony.