Abstract: Microsphere formulations comprising asenapine are provided. Methods for making and using the microsphere formulations are also provided.

Abstract: A rotor assembly for use in a radial flux electric motor assembly is provided. The rotor assembly includes a rotor core having a plurality of circumferentially spaced rotor poles and a plurality of magnets alternately spaced with the plurality of rotor poles. The plurality of rotor poles define a radial aperture between each pair of circumferentially adjacent rotor poles, and each radial aperture is configured to receive a magnet of the plurality of magnets therein. The rotor assembly further includes an end cap coupled to the rotor core and to the plurality of core magnets. The end cap includes a plurality of deformable members positioned between the rotor core and the plurality of magnets and configured to restrict movement of the plurality of magnets within the radial apertures. The deformable members are configured to deform upon insertion into a cavity defined between the rotor core and the plurality of magnets.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.

Abstract: Microsphere formulations comprising naltrexone are provided. Methods of making and using the microsphere formulations are also provided.

Abstract: A rotor assembly for use in a radial flux electric motor assembly is provided. The rotor assembly includes a rotor core having a plurality of circumferentially spaced rotor poles and a plurality of magnets alternately spaced with the plurality of rotor poles. The plurality of rotor poles define a radial aperture between each pair of circumferentially adjacent rotor poles, and each radial aperture is configured to receive a magnet of the plurality of magnets therein. The rotor assembly further includes an end cap coupled to the rotor core and to the plurality of core magnets. The end cap includes a plurality of deformable members positioned between the rotor core and the plurality of magnets and configured to restrict movement of the plurality of magnets within the radial apertures. The deformable members are configured to deform upon insertion into a cavity defined between the rotor core and the plurality of magnets.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.