Abstract: A helical distractor, including: a distractor body having an open tubular shape including: a fixed footplate attached to a first end of the distractor body; first and second body edges; first and second key grooves in the first and second body edges, respectively; and an end cap at a second end of the distractor body; a movable foot including: body threads; a first key configured to engage the first key groove; a second key configured to engage the second key groove; and a movable footplate; an advancement screw with a threaded portion inside the distraction body, wherein the threaded portion is configured to engage the body threads of the movable foot, wherein the movable foot moves along the distractor body when the advancement screw is rotated, and wherein the distractor body is configured to cause the movable foot to rotate as it moves along the distractor body.

Abstract: The present invention pertains to a method for identifying anti-cancer compounds. The invention is based on the finding that a direct protein-protein interaction between 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and (F-box protein 28) FBXO28 silences a ubiquitin E3 ligase activity of FBXO28 towards HIF1a. Interfering with this protein-protein interaction leads to a strong induction of HIF1a proteasomal degradation and cell death in tumors, and therefore, compounds screened according to the present invention harbour therapeutic potential for the treatment of proliferative diseases such as cancer. The invention provides a screening method for cancer therapeutics based on the interaction of PFKFB4 and FBXO28, as well medical applications thereof.

Abstract: Some embodiments may provide a revolutionary cosmetic product to reduce the appearance of fine lines and/or wrinkles in a person's skin. In particular, an anti-wrinkle system may include a substantially flat silicone pad to be affixed to a person's skin (e.g., in an area around the person's chest, torso, neck, face, hands, backside, knees, etc.) and an activator substance to be applied between the silicone pad and the person's skin, including a humectant and a ferment in a suitable carrier. The activator substance might be associated with, for example, a gel, a cream, a lotion, a serum, and/or a mist. According to some embodiments, the anti-wrinkle medical grade silicone pad uses a mixture of ingredients harnessing them to represent a breakthrough, game-changing advance in the field of cosmetics that enhances the benefits of the anti-wrinkle medical grade silicone pad through additional wrinkle reduction beyond the anti-wrinkly pad alone.

Abstract: Some embodiments described herein provide a revolutionary cosmetic product to reduce the appearance of fine lines and/or wrinkles in a person's skin. In particular, an anti-wrinkle pad may include an anti-wrinkle portion and may have at least one characteristic to reduce an appearance of fine lines and/or wrinkles on a person's skin in an area around the person's chest, torso, neck, face, hands, backside, knees, etc. The anti-wrinkle pad may further include an adhesive substrate affixed to the lower surface of the anti-wrinkle portion and adapted to adhere the anti-wrinkle portion to the person's skin. According to some embodiments, the anti-wrinkle portion is formed by: blending together a plurality of materials; and placing the blended materials into a compression apparatus to form, using heat and/or pressure, the anti-wrinkle portion.