Abstract: A low dose drug delivery pod comprised of a reciprocating pump, an active valve set, and, in some embodiments, a dispense confirmation sensor. The active valve set can be designed with mechanical interference between them so that both the inlet and outlet valve must close before either one opens, ensuring that at least one of the two valves is closed at all times. The dispense confirmation sensor is a flow-based detection system that provides rapid feedback if an individual dose has or has not been delivered.