Patents by Inventor Emma R. Parmee

Emma R. Parmee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
    Publication number: 20100130504
    Abstract: The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 27, 2010
    Inventors: Scott D. Edmondson, Michael H. Fisher, Dooseop Kim, Malcolm Maccoss, Emma R. Parmee, Ann E. Weber, Jinyou Xu
  • Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
    Patent number: 7687534
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: March 30, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John E. Stelmach, Emma R. Parmee, James R. Tata, Keith G. Rosauer, Ronald M. Kim, Amy R. Bittner, Jiang Chang, Christopher Joseph Sinz
  • Pyrazole amide derivatives, compositions containing such compounds and methods of use
    Patent number: 7649009
    Abstract: Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: January 19, 2010
    Assignee: Merck & Co., Inc.
    Inventors: Teresa Beeson, Linda Brockunier, Emma R. Parmee, Subharekha Raghavan
  • GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
    Publication number: 20100004158
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: September 27, 2007
    Publication date: January 7, 2010
    Inventors: John E. Stelmach, Emma R. Parmee, James R. Tata, Keith G. Rosauer, Ronald M. Kim, Amy R. Bittner, Jiang Chang, Christopher Joseph Sinz
  • Substituted pyrazoles, compositions containing such compounds and methods of use
    Patent number: 7625938
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: December 1, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Linda Brockunier, Jian Guo, Rui Liang, Emma R. Parmee, Subharekha Raghavan, George Scott Tria, Yusheng Xiong
  • Acyl indoles, compositions containing such compounds and methods of use
    Patent number: 7598398
    Abstract: The present invention relates to substituted indoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus and related conditions.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: October 6, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Ronald M. Kim, Amy R. Bittner, Christopher Joseph Sinz, Emma R. Parmee
  • Pyrazole derivatives, compositions containing such compounds and methods of use
    Patent number: 7598285
    Abstract: Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: October 6, 2009
    Assignee: Merck & Co., Inc
    Inventors: Emma R. Parmee, Yusheng Xiong, Jian Guo, Rui Liang, Linda Brockunier
  • SOLUBLE GUANYLATE CYCLASE ACTIVATORS
    Publication number: 20090209556
    Abstract: A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.
    Type: Application
    Filed: April 27, 2009
    Publication date: August 20, 2009
    Inventors: Amy R. Bittner, Christopher Joseph Sinz, Jiang Chang, Ronald M. Kim, J. W. Mirc, Emma R. Parmee, Qiang Tan
  • Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds And Methods Of Use
    Publication number: 20090209564
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: March 19, 2007
    Publication date: August 20, 2009
    Inventors: Ronald M. Kim, Emma R. Parmee, Qiang Tan, Ashley Rouse Lins, Jiang Chang, Cangming Yang
  • Benzamidazoles, compositions containing such compounds and methods of use
    Patent number: 7563815
    Abstract: The present invention relates to substituted benzimidazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: July 21, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Emma R. Parmee, Ronald M. Kim, Rui Liang, Jiang Chang, Elizabeth Ashley Rouse, Kevin T. Chapman
  • PYRAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
    Publication number: 20090176854
    Abstract: Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: March 17, 2009
    Publication date: July 9, 2009
    Inventors: Emma R. Parmee, Yusheng Xiong, Jian Guo, Rui Liang, Linda Brockunier
  • Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds and Methods of Use
    Publication number: 20090105310
    Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: May 11, 2007
    Publication date: April 23, 2009
    Inventors: Ronald M. Kim, Emma R. Parmee, Qiang Tan, Cangming Yang, Ashley Rouse Lins
  • Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
    Publication number: 20090054506
    Abstract: Substituted aryl and heteroaryl derivatives are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: March 24, 2006
    Publication date: February 26, 2009
    Inventors: Rui Liang, Emma R. Parmee
  • Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    Patent number: 7456204
    Abstract: The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: November 25, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Scott D. Edmondson, Anthony Mastracchio, Emma R. Parmee
  • Substituted Aryl and Heteroaryl Derivatives, Compositions Containing Such Compounds and Methods of Use
    Publication number: 20080161347
    Abstract: Substituted aryl and heteroaryl derivatives are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Application
    Filed: March 17, 2006
    Publication date: July 3, 2008
    Applicant: MERCK & CO., INC.
    Inventors: John E. Stelmach, Keith G. Rosauer, Emma R. Parmee, James R. Tata
  • Substituted Pyrazoles, Compositions Containing such Compounds and Methods of Use
    Publication number: 20080108620
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Application
    Filed: July 19, 2005
    Publication date: May 8, 2008
    Applicant: MERCK & CO., INC.
    Inventors: Linda Brockunier, Jian Guo, Rui Liang, Emma R. Parmee, Subharekha Raghavan, George Scott Tria, Yusheng Xiong
  • Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    Patent number: 7332520
    Abstract: The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: February 19, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Scott D. Edmondson, Anthony Mastracchio, Emma R. Parmee
  • ?-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    Patent number: 7307164
    Abstract: The present invention is directed to compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: December 11, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Linda L. Brockunier, Joseph L. Duffy, Dooseop Kim, Emma R. Parmee, Ann E. Weber
  • Cyclic guanidines, compositions containing such compounds and methods of use
    Patent number: 7301036
    Abstract: The present invention relates to cyclic guanidines, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: November 27, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Emma R. Parmee, Ronald M. Kim, Elizabeth A. Rouse, Darby R. Schmidt, Christopher Joseph Sinz, Jiang Chang
  • Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    Patent number: 7125873
    Abstract: The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: October 24, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Scott D Edmondson, Michael H. Fisher, Dooseop Kim, Malcolm Maccoss, Emma R. Parmee, Ann E Weber, Jinyou Xu