Patents by Inventor Emmanuel Aubrey Margolin

Emmanuel Aubrey Margolin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Co-expression of human chaperone proteins in plants for increased expression of heterologous polypeptides
    Patent number: 11555196
    Abstract: The present invention relates to a method for increasing the expression and/or promoting correct folding of a heterologous polypeptide of interest in a plant cell, comprising co-expressing the heterologous polypeptide of interest with a polypeptide encoding a mammalian chaperone protein. The invention also relates to plant cells and plants, which either transiently or stably, co-express the heterologous polypeptide of interest and the chaperone protein.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 17, 2023
    Assignee: UNIVERSITY OF CAPE TOWN
    Inventors: Ann Elizabeth Meyers, Edward Peter Rybicki, Emmanuel Aubrey Margolin
  • DEVELOPMENT OF AN EDIBLE VACCINE
    Publication number: 20220054628
    Abstract: Plant-based, edible vaccines are provided. The vaccines are or are made from plants that are genetically engineered to express antigens of disease-causing microbes, for example, antigens of the MERS-CoV virus, such as the S1 subunit of the spike protein.
    Type: Application
    Filed: August 19, 2020
    Publication date: February 24, 2022
    Inventors: Sayed Sartaj SOHRAB, Esam Ibraheem Ahmed ASHAR, Sherif Aly Abdelkhalek ELKAFRAWY, Ayman Talaat Abbas Abdelhadi, Edward P. RYBICKI, Emmanuel Aubrey MARGOLIN
  • Co-Expression of Human Chaperone Proteins in Plants for Increased Expression of Heterologous Polypeptides
    Publication number: 20210147860
    Abstract: The present invention relates to a method for increasing the expression and/or promoting correct folding of a heterologous polypeptide of interest in a plant cell, comprising co-expressing the heterologous polypeptide of interest with a polypeptide encoding a mammalian chaperone protein. The invention also relates to plant cells and plants, which either transiently or stably, co-express the heterologous polypeptide of interest and the chaperone protein.
    Type: Application
    Filed: June 1, 2018
    Publication date: May 20, 2021
    Inventors: Ann Elizabeth Meyers, Edward Peter Rybicki, Emmanuel Aubrey Margolin
  • Production of soluble HIV envelope trimers in planta
    Patent number: 10899801
    Abstract: The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: January 26, 2021
    Assignee: University of Cape Town
    Inventors: Ann Elizabeth Meyers, Anna-Lise Williamson, Edward Peter Rybicki, Emmanuel Aubrey Margolin, Rosamund Chapman
  • PRODUCTION OF SOLUBLE HIV ENVELOPE TRIMERS IN PLANTA
    Publication number: 20190337994
    Abstract: The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.
    Type: Application
    Filed: October 13, 2017
    Publication date: November 7, 2019
    Inventors: Ann Elizabeth Meyers, Anna-Lise Williamson, Edward Peter Rybicki, Emmanuel Aubrey Margolin, Rosamund Chapman