Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).

Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

Abstract: The present invention relates to the use of an aqueous composition for dissolving biomolecules from a tissue sample and to a method of using an aqueous composition for dissolving biomolecules from a tissue sample. Furthermore, the present invention relates to a system for preparing a tissue sample of an animal.

Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. those in the scheme below: which intermediates and processes are useful in the preparation of the macrocyclic HVC inhibitor Simeprevir.

Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

Abstract: A storage unit is disclosed for at least one animal identification and/or animal tissue collecting device, capable of storing said at least one identification and/or collecting device. In several embodiments, such a set includes at least one container containing a specific agent designed to be applied at least partially to at least one element of said identification and/or collecting device.

Abstract: The invention relates to a device for identifying an animal, comprising a male part and a female part which are intended to be joined together, said female part comprising a head (12) for holding a tip of said male part, and a rigid shell (11) containing electronic identification means (42). According to the invention, a resin (41) is placed inside a housing defined in said shell so as to cover said electronic means (42) and to secure said head (12) to said shell (11).

Abstract: The invention relates to a device for identifying an animal, comprising a male part and a female part which are intended to be joined together, said female part comprising a head (12) for holding a tip of said male part, and a rigid shell (11) containing electronic identification means (42). According to the invention, a resin (41) is placed inside a housing defined in said shell so as to cover said electronic means (42) and to secure said head (12) to said shell (11).

Abstract: Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods are disclosed.

Abstract: A storage unit is disclosed for at least one animal identification and/or animal tissue collecting device, capable of storing said at least one identification and/or collecting device. In several embodiments, such a set includes at least one container containing a specific agent designed to be applied at least partially to at least one element of said identification and/or collecting device.

Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

Abstract: An auricular label includes a fastening system that combines, with a male part, a female part including a button having an opening and a cavity for receiving the male portion, the button including an essentially cylindrical or frusto-conical head and a circular surface extending in a plane substantially perpendicular to the axis of the head from the base thereof, the loop being characterized in that the surface of the reception button includes at least two perforations ensuring the communication of the lower face of the surface with the atmosphere. The label ensures an improved healing of the insertion point into the ear of the animal, without impairing the rigidity or the solidity of the button, and without permitting the forced extraction of the male part or any other manipulation for forging the data contained in the ring.

Abstract: The invention relates to a marking device for identifying and marking an animal that is connected by a non-reversible engagement: a male portion (2) including a rod extending from a holder (10); and a female portion (5) including a cavity for interaction with a rod.

Abstract: Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol and especially its enantiomer (3R,3aS,6aR) hexahydrofuro[2,3-b]furan-3-ol, as well as certain novel intermediates for use in such methods.

Abstract: A supporting and guiding device for railway vehicles has at least four wheels 1, 2 mounted on a support intended to be fixed to the body 3 of a vehicle near one end thereof. The device includes a cross bar 8 maintained perpendicular to the vertical plane containing the longitudinal axis of the vehicle, and two longitudinal beams 5 which each carry at least two wheels. In use the beams extend longitudinally of the body on both sides of the vertical plane, and they are connected to each other by a rod 12 mounted on ball and socket joints 13.The longitudinal beams are hinged (9) to the common cross bar such that the wheels carried by the beams may become oriented in order to follow the curves of the track rails 6 and to be moved in order to pass over inequalities or unevennesses of said track.