Patents by Inventor Emmanuel Le Poul

Emmanuel Le Poul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Allosteric modulators of metabotropic glutamate receptors
    Patent number: 8163775
    Abstract: The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R1 and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: April 24, 2012
    Assignee: Addex Pharma SA
    Inventors: Anne-Sophie Bessis, Beatrice Bonnet, Emmanuel Le Poul, Jean-Philippe Rocher, Mark Epping-Jordan
  • ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
    Publication number: 20120022108
    Abstract: The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R1 and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Application
    Filed: September 30, 2011
    Publication date: January 26, 2012
    Applicant: Addex Pharma SA
    Inventors: Anne-Sophie Bessis, Beatrice Bonnet, Emmanuel Le Poul, Jean-Philippe Rocher, Mark Eppig-Jordan
  • Allosteric modulators of metabotropic glutamate receptors
    Patent number: 8030331
    Abstract: The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R1 and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: October 4, 2011
    Assignee: Addex Pharma SA
    Inventors: Anne-Sophie Bessis, Beatrice Bonnet, Emmanuel Le Poul, Jean-Philippe Rocher, Mark Epping-Jordan
  • Methods of making an antibody that binds a chemerin polypeptide
    Patent number: 8030453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: October 4, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
    Publication number: 20110112143
    Abstract: The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R1 and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Application
    Filed: October 6, 2010
    Publication date: May 12, 2011
    Applicant: Addex Pharma SA
    Inventors: Anne-Sophie Bessis, Beatrice Bonnet, Emmanuel Le Poul, Jean-Philippe Rocher, Mark Epping-Jordan
  • COMPOSITIONS AND METHODS COMPRISING A LIGAND OF CHEMERINR
    Publication number: 20110033467
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: February 19, 2009
    Publication date: February 10, 2011
    Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Allosteric modulators of metabotropic glutamate receptors
    Patent number: 7834035
    Abstract: The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R1 and R2 are defined in the description; invention compounds are useful in the prevention or treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: November 16, 2010
    Assignee: Addex Pharma SA
    Inventors: Anne-Sophie Bessis, Beatrice Bonnet, Emmanuel Le Poul, Jean-Philippe Rocher, Mark Epping-Jordan
  • COMPOSITIONS AND METHODS COMPRISING A LIGAND OF CHEMERINR
    Publication number: 20100267138
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: February 19, 2009
    Publication date: October 21, 2010
    Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
    Publication number: 20100081690
    Abstract: The present invention provides new compounds of formula I, wherein P, A, W, B, Q, R1 and R2 are defined as in formula I; invention compounds are positive allosteric modulators of metabotropic receptors—subtype 5 (“mGluR5”) which are useful for the treatment or prevention of central nervous system disorders such as for example: cognitive decline, both positive and negative symptoms in schizophrenia as well as other disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved.
    Type: Application
    Filed: November 7, 2007
    Publication date: April 1, 2010
    Applicant: ADDEX PHARMA SA
    Inventors: Emmanuel Le Poul, Giovanni Palombi, Jean-Philippe Rocher
  • Compositions and methods comprising a ligand of chemerin R
    Publication number: 20100009345
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: October 26, 2007
    Publication date: January 14, 2010
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, Daivd Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors
    Publication number: 20100004284
    Abstract: The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.
    Type: Application
    Filed: May 17, 2006
    Publication date: January 7, 2010
    Applicant: ADDEX PHARMA SA
    Inventors: Marco Farina, Stefania Gagliardi, Emmanuel Le Poul, Giovanni Palombi, Jean-Philippe Rocher
  • Substituted Oxadiazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate Receptors
    Publication number: 20090215822
    Abstract: The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.(I).
    Type: Application
    Filed: May 17, 2006
    Publication date: August 27, 2009
    Applicants: NIKEM RESEARCH SRL, ADDEX PHARMA SA
    Inventors: Marco Farina, Stefania Gagliardi, Emmanuel Le Poul, Vincent Mutel, Giovanni Palombi, Sonia-Maria Poli, Jean-Philippe Rocher
  • Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors
    Publication number: 20090203737
    Abstract: The present invention relates to new compounds which are Pyrrole derivatives of formula (I) wherein A, B, P, Q5W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Application
    Filed: May 17, 2006
    Publication date: August 13, 2009
    Inventors: Stefania Gagliardi, Emmanuel Le Poul, Iain Lingard, Giovanni Palombi, Sonia-Maria Poli, Jean-Philippe Rocher
  • Novel Oxadiazole Derivatives and Their Use as Positive Allosteric Modulators of Metabotropic Glutamate Receptors
    Publication number: 20090197897
    Abstract: The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.
    Type: Application
    Filed: May 17, 2006
    Publication date: August 6, 2009
    Applicant: Addex Pharma SA
    Inventors: Piergiuliano Bugada, Stefania Gagliardi, Emmanuel Le Poul, Vincent Mutel, Giovanni Palombi, Jean-Philippe Rocher
  • Compositions and Methods Comprising a Ligand of ChemerinR
    Publication number: 20090081729
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Compositions and methods comprising a ligand of chemerin R
    Publication number: 20090047741
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 19, 2009
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Antibody that specifically binds to Chemerin receptor ligand precursor
    Patent number: 7470772
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: December 30, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Isolated ligand of ChemerinR
    Patent number: 7419658
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: September 2, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Compositions comprising a ligand of chemerinR
    Publication number: 20080125357
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: March 13, 2006
    Publication date: May 29, 2008
    Inventors: Valerie Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Methods of identifying modulators of ligand binding to ChemerinR polypeptides
    Patent number: 7332291
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 19, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valérie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stéphane Brézillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul