Patents by Inventor Emmanuel Mertens

Emmanuel Mertens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of detoxification
    Patent number: 8815254
    Abstract: The present invention relates to a method of detoxifying bacterial cytolysins such as pneumococcal pneumolysin, utilizing chemical cross-linking compounds.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: August 26, 2014
    Assignee: GlaxoSmithKline Biologicals, S.A.
    Inventors: Ralph Biemans, Karine Goraj, Emmanuel Mertens, Annick Vandercammen
  • METHOD OF DETOXIFICATION
    Publication number: 20140010843
    Abstract: The present invention relates to a method of detoxifying bacterial cytolysins such as pneumococcal pneumolysin, utilizing chemical cross-linking compounds.
    Type: Application
    Filed: September 27, 2012
    Publication date: January 9, 2014
    Inventors: Ralph BIEMANS, Karine Goraj, Emmanuel Mertens, Annick Vandercammen
  • Method of producing an immunogenic composition
    Patent number: 8309327
    Abstract: The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 13, 2012
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventors: Ralph Biemans, Karine Goraj, Emmanuel Mertens, Annick Vandercammen
  • Purification process for bacterial cytolysin
    Patent number: 8084235
    Abstract: The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: December 27, 2011
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventors: Ralph Biemans, Karine Goraj, Emmanuel Mertens, Annick Vandercammen
  • METHOD OF PRODUCING A VACCINE
    Publication number: 20110311577
    Abstract: The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
    Type: Application
    Filed: August 31, 2011
    Publication date: December 22, 2011
    Inventors: Ralph Biemans, Karine Goraj, Emmanuel Mertens, Annick Vandercammen
  • Purification Process for Bacterial Cytolysin
    Publication number: 20070231876
    Abstract: The present application relates to a process for purification of a bacterial cytolysin comprising the steps of a) growing a culture of cells expressing bacterial cytolysin, b) mechanically breaking the culture of cells to form an extract, c) prefiltering the extract, d) binding soluble aggregated bacterial cytolysin contained in the extract in the presence of detergent to a hydrophobic interaction chromatography material under high salt (preferably 0.6-2M salt) conditions, and e) eluting bacterial cytolysin in the presence of detergent under low salt (preferably 0-0.2M salt) conditions.
    Type: Application
    Filed: September 20, 2005
    Publication date: October 4, 2007
    Inventors: Ralph Biemans, Carine Goraj, Emmanuel Mertens, Anne Vandercammen