Patents by Inventor En-Te Hwu
En-Te Hwu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12220703Abstract: A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.Type: GrantFiled: December 20, 2021Date of Patent: February 11, 2025Assignee: Danmarks Tekniske UniversitetInventors: Anja Boisen, En-Te Hwu, Kinga Iudith Zor, Sriram Thoppe Ranjendran, Laura Serioli
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Patent number: 12168228Abstract: A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.Type: GrantFiled: October 24, 2019Date of Patent: December 17, 2024Assignee: Danmarks Tekniske UniversitetInventors: Anja Boisen, En-Te Hwu, Kinga Iudith Zor, Sriram Thoppe Ranjendran, Laura Serioli
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Publication number: 20240227290Abstract: Disclosed is a method of 3D-printing a polymer-based structure comprising at least one polymer-based substructure. The method comprised the steps of depositing a photocurable resin onto a spinnable substrate, spin coating a layer comprising said photocurable resin on said spinnable substrate by spinning said spinnable substrate, and irradiating said layer, while spinning said spinnable substrate, at one or more selected positions with a light source to cure at least a portion of said layer, thereby forming a polymer-based substructure. A system for 3D-printing a polymer-based structure comprising at least one polymer-based substructure is further disclosed.Type: ApplicationFiled: March 1, 2022Publication date: July 11, 2024Applicant: Danmarks Tekniske UniversitetInventors: Anja Boisen, En-Te Hwu, Tien-Jen Chang
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Publication number: 20220111384Abstract: A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.Type: ApplicationFiled: December 20, 2021Publication date: April 14, 2022Inventors: Anja Boisen, En-Te Hwu, Kinga Iudith Zor, Sriram Thoppe Ranjendran, Laura Serioli
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Publication number: 20220008923Abstract: A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.Type: ApplicationFiled: October 24, 2019Publication date: January 13, 2022Inventors: Anja Boisen, En-Te Hwu, Kinga Iudith Zor, Sriram Thoppe Ranjendran, Laura Serioli
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Patent number: 10145861Abstract: A detection device having an attached probe, the detection device including a base body (100) and a probe (200). The base body (100) is provided with a stage (140), the probe (200) is provided with a probe base body (210) and a tip (220) extending from a side surface of one end of the probe base body (210), another end of the probe base body (210) is adhered to the base body (100) via an adhesion piece (230), the probe base body (210) can be removed from the base body (100), and the tip (220) is close to the stage (140) and deployed in the direction thereof. The probe base body (210) is directly attached to the base body (100) and easily removed therefrom. It is therefore easy to replace the probe (200).Type: GrantFiled: December 29, 2015Date of Patent: December 4, 2018Assignee: STROMLINET NANO LIMITEDInventor: En-Te Hwu
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Publication number: 20170363657Abstract: A detection device having an attached probe, the detection device including a base body (100) and a probe (200). The base body (100) is provided with a stage (140), the probe (200) is provided with a probe base body (210) and a tip (220) extending from a side surface of one end of the probe base body (210), another end of the probe base body (210) is adhered to the base body (100) via an adhesion piece (230), the probe base body (210) can be removed from the base body (100), and the tip (220) is close to the stage (140) and deployed in the direction thereof. The probe base body (210) is directly attached to the base body (100) and easily removed therefrom. It is therefore easy to replace the probe (200).Type: ApplicationFiled: December 29, 2015Publication date: December 21, 2017Applicant: Stromlinet Nano LimitedInventor: En-Te HWU
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Patent number: 9784735Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.Type: GrantFiled: March 24, 2014Date of Patent: October 10, 2017Assignee: Danmarks Tekniske UniversitetInventors: Marco Donolato, Filippo Bosco, Mikkel Fougt Hansen, Anja Boisen, En-Te Hwu
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Publication number: 20160377609Abstract: The present invention relates to an apparatus for detecting compounds, the apparatus having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices.Type: ApplicationFiled: November 17, 2015Publication date: December 29, 2016Inventors: Anja Boisen, Filippo Giacomo Bosco, En-Te Hwu
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Publication number: 20160146798Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.Type: ApplicationFiled: March 24, 2014Publication date: May 26, 2016Inventors: Marco DONOLATO, Filippo BOSCO, Mikkel Fougt HANSEN, Anja BOISEN, En-Te HWU
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Patent number: 9190938Abstract: A piezoelectric actuating device includes a carrier, at least a piezoelectric unit, at least a linked component and a moving component. The piezoelectric unit is disposed on the carrier and includes at least a piezoelectric buzzer. The linked component is disposed corresponding to the piezoelectric unit. One end of the linked component is attached to the piezoelectric buzzer. The moving component is connected with the linked component. When the piezoelectric buzzer is actuated, it can carry the linked component to move correspondingly so as to move the moving component. The piezoelectric actuating device has the advantage of low cost and can achieve the sub-nanometer scale actuating resolution.Type: GrantFiled: March 4, 2013Date of Patent: November 17, 2015Assignee: Academia SinicaInventors: En-Te Hwu, Ing-Shouh Hwang, Wei-Min Wang
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Patent number: 9075245Abstract: An optical module includes at least a carrying stage, at least an actuator unit and at least an optical assembly. The carrying stage has a first aperture. The actuator unit is disposed at one side of the carrying stage and has a second aperture. The optical assembly is connected with the actuator unit, and the actuator unit adjusts the position of the optical assembly. A radiated wave enters from one side of the optical module and passes through the first aperture, the second aperture and the optical assembly. A microscope with the optical module has compact size and is easily assembled and carried. The optical module and microscope can efficiently reduce the effect of ambient temperature variations so as to improve the measuring stability thereof.Type: GrantFiled: January 3, 2013Date of Patent: July 7, 2015Assignee: ACADEMIA SINICAInventor: En-Te Hwu
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Patent number: 8912707Abstract: An apparatus for actuating a positioning device includes a housing; a piezoelectric element connected to the housing; a driven element configured to move relative to the housing; and a flexible element connected to the piezoelectric element and configured to transfer a motion of the piezoelectric element to the driven element.Type: GrantFiled: July 13, 2011Date of Patent: December 16, 2014Assignee: Academia SinicaInventors: En-Te Hwu, Hsien-Shun Liao, Ing-Shouh Hwang
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Patent number: 8893627Abstract: A linear actuator includes a housing, a rotary unit disposed in the housing, and a screw member driven by the rotary unit. The rotary unit is translatable relative to the housing when the screw member is driven by the rotary unit.Type: GrantFiled: April 2, 2013Date of Patent: November 25, 2014Assignee: Academia SinicaInventors: En-Te Hwu, Ing-Shouh Hwang, Wei-Min Wang
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Patent number: 8606426Abstract: A system includes a displacement sensor, an actuator connected to the displacement sensor, and a feedback unit. The displacement sensor is configured to measure at least one of a relative position and a relative orientation between the displacement sensor and the target object. The feedback unit receives a signal from the displacement sensor related to the measured relative position or relative orientation and controls the actuator to move the displacement sensor on the basis of variations in the received signal arising due to a change in environmental conditions.Type: GrantFiled: October 23, 2009Date of Patent: December 10, 2013Assignee: Academia SinicaInventors: Ing-Shouh Hwang, En-Te Hwu, Hans Ulrich Danzebrink, Hartmut Illers
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Publication number: 20130291669Abstract: A linear actuator includes a housing, a rotary unit disposed in the housing, and a screw member driven by the rotary unit. The rotary unit is translatable relative to the housing when the screw member is driven by the rotary unit.Type: ApplicationFiled: April 2, 2013Publication date: November 7, 2013Applicant: Academia SinicaInventors: En-Te HWU, Ing-Shouh HWANG, Wei-Min WANG
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Patent number: 8569932Abstract: A multi-axis actuating apparatus for a nano-positioning apparatus includes a movable element attached to a sample platform, a plurality of driving elements, and a plurality of actuators. The driving elements frictionally engage the movable element and are configured to selectively move the movable element along a first direction. The plurality of actuators move the plurality of driving elements when driving signals are applied to the plurality of actuators. Different driving signals may be applied to the plurality of actuators to cause different movement of the driving elements such that the movable element has different displacements in different directions along the plurality of driving elements. The movable element is titled due to the different displacements.Type: GrantFiled: October 4, 2011Date of Patent: October 29, 2013Assignee: Academia SinicaInventors: En-Te Hwu, Ing-Shouh Hwang
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Publication number: 20130210027Abstract: The present invention relates to an apparatus for detecting compounds, the apparatus having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices.Type: ApplicationFiled: September 21, 2011Publication date: August 15, 2013Applicant: DANMARKS TEKNISKE UNIVERSITETInventors: Anja Boisen, Filippo Giacomo Bosco, En-Te Hwu
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Publication number: 20130015745Abstract: An apparatus for actuating a positioning device includes a housing; a piezoelectric element connected to the housing; a driven element configured to move relative to the housing; and a flexible element connected to the piezoelectric element and configured to transfer a motion of the piezoelectric element to the driven element.Type: ApplicationFiled: July 13, 2011Publication date: January 17, 2013Applicant: Academia SinicaInventors: En-Te Hwu, Hsien-Shun Liao, Ing-Shouh Hwang
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Publication number: 20120306317Abstract: A multi-axis actuating apparatus for a nano-positioning apparatus includes a movable element attached to a sample platform, a plurality of driving elements, and a plurality of actuators. The driving elements frictionally engage the movable element and are configured to selectively move the movable element along a first direction. The plurality of actuators move the plurality of driving elements when driving signals are applied to the plurality of actuators. Different driving signals may be applied to the plurality of actuators to cause different movement of the driving elements such that the movable element has different displacements in different directions along the plurality of driving elements. The movable element is titled due to the different displacements.Type: ApplicationFiled: October 4, 2011Publication date: December 6, 2012Applicant: Academia SinicaInventors: En-Te Hwu, Ing-Shouh Hwang