Patents by Inventor Endre Mikulásik
Endre Mikulásik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11154535Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: GrantFiled: September 13, 2013Date of Patent: October 26, 2021Assignee: EGIS Pharmaceuticals PLCInventors: Endre Mikulásik, Tamás Spaits, Ágota Szakálynè Sinka
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Patent number: 10441660Abstract: The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.Type: GrantFiled: August 28, 2017Date of Patent: October 15, 2019Assignee: EGIS GYOCYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Endre Mikulásik, Patrik Fazekas
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Patent number: 10045935Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: GrantFiled: July 31, 2012Date of Patent: August 14, 2018Assignee: EGIS PHARMACEUTICALS PLCInventors: Endre Mikulásik, Tamás Spaits, Ágota Szakályné Sinka
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Patent number: 10045965Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: GrantFiled: April 9, 2015Date of Patent: August 14, 2018Assignee: EGIS Pharmaceuticals PLCInventors: Endre Mikulásik, Tamás Spaits, Ágota Szakályné Sinka
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Publication number: 20180071395Abstract: The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.Type: ApplicationFiled: August 28, 2017Publication date: March 15, 2018Inventors: Endre Mikulásik, Patrik Fazekas
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Patent number: 9775908Abstract: The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.Type: GrantFiled: July 10, 2008Date of Patent: October 3, 2017Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Endre Mikulásik, Patrik Fazekas
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Publication number: 20150231247Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: ApplicationFiled: April 9, 2015Publication date: August 20, 2015Inventors: Endre Mikulásik, Thomás Spaits, Ágota Szakályné Sinka
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Publication number: 20150209329Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: ApplicationFiled: April 9, 2015Publication date: July 30, 2015Inventors: Endre Mikulásik, Tamás Spaits, Ágota Szakályné Sinka
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Patent number: 8883860Abstract: A method for purifying diatomaceous earth, whose natural colloidal structure is retained, which includes preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product.Type: GrantFiled: October 12, 2011Date of Patent: November 11, 2014Assignees: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag, ONP Holdings SEInventors: Endre Mikulásik, Tamás Spaits, Kálmán Nagy, Gyula Lukács, Imre Markovits, Krisztina Fodorné Kocsmár, Livia Gregorné Boros, Tamás Mórász, László Szlávik, Máté Hudák, Gyöngyi Heréb, Réka Eszter Puskás, Zoltán Varga, Imre Kapui, György Clementis, Gábor Attila Bacher, Beatrix Bánkövi, Gitta Kiss, Ottó Albrecht
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Publication number: 20140161889Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: ApplicationFiled: February 13, 2014Publication date: June 12, 2014Applicant: EGIS PHARMACEUTICALS PLCInventors: Endre Mikulásik, Tamás Spaits, Ágota Szakálynè Sinka
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Publication number: 20140079791Abstract: The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.Type: ApplicationFiled: November 15, 2013Publication date: March 20, 2014Applicant: EGIS Pharmaceuticals Public Limited CompanyInventors: Endre Mikulásik, Patrik Fazekas
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Publication number: 20140037738Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: ApplicationFiled: July 31, 2012Publication date: February 6, 2014Applicant: EGIS PHARMACEUTICALS PLCInventors: Endre MIKULÁSIK, Tamás SPAITS, Ágota SZAKÁLYNÉ SINKA
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Publication number: 20140039028Abstract: Disclosed are gel compositions suitable for the topical administration of an active compound having poor solubility and skin penetration, for example, of a COX-2 inhibitor compounds, processes of preparation thereof and methods of use thereof for the treatment of indications treatable by the active compound.Type: ApplicationFiled: September 13, 2013Publication date: February 6, 2014Applicant: EGIS Pharmaceuticals PLCInventors: Endre Mikulásik, Tamás Spaits, Ágota Szakálynè Sinka
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Publication number: 20130225695Abstract: The present invention is related to a method for purifying diatomaceous earth wherein the natural colloidal structure of the material is retained, which comprises preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product. The invention also relates to a product obtainable by the above-mentioned method.Type: ApplicationFiled: October 12, 2011Publication date: August 29, 2013Applicants: ONP HOLDINGS SE, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Endre Mikulásik, Tamás Spaits, Kálmán Nagy, Gyula Lukács, Imre Markovits, Krisztina Fodorné Kocsmár, Livia Gregorné Boros, Tamás Mórász, László Szlávik, Máté Hudák, Gyöngyi Heréb, Réka Eszter Puskás, Zoltán Varga, Imre Kapui, György Clementis, Gábor Attila Bacher, Beatrix Bánkövi, Gitta Kiss, Ottó Albrecht
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Publication number: 20130149380Abstract: The present invention is related to solid pharmaceutical preparations containing diatomaceous earth (diatomite) or a natural mineral mixture containing diatomaceous earth as filler besides the active ingredient and optional other auxiliary agents. A further object of the invention is a method for manufacturing such pharmaceutical preparations.Type: ApplicationFiled: May 27, 2011Publication date: June 13, 2013Applicants: ONP HOLDINGS SE, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Endre Mikulásik, Ottó Albrecht
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Publication number: 20120167671Abstract: The invention relates to an apparatus and method for testing transdermal medicaments, wherein the sample tested in a membrane penetration cell resides in the open sample compartment of said cell and is exposed to environmental factors such as temperature, air flow, light and air humidity during testing the absorption and penetration.Type: ApplicationFiled: February 8, 2010Publication date: July 5, 2012Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Endre Mikulásik, Patrik Fazekas, Péter Szakály
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Publication number: 20120024743Abstract: The present invention relates to semisolid transdermal pharmaceutical preparation having enhanced stability and bioavailability, wherein the particles are coated by a volatile silicon oil component and the thus obtained suspension is dispersed in a gel or cream base.Type: ApplicationFiled: February 5, 2010Publication date: February 2, 2012Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAGInventors: Endre Mikulasik, Patrik Fazekas
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Publication number: 20100215756Abstract: The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.Type: ApplicationFiled: July 10, 2008Publication date: August 26, 2010Inventors: Endre Mikulásik, Patrik Fazekas