Patents by Inventor Endre Mikus

Endre Mikus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolidinyl-alkyl-amide derivatives, their preparation, and their therapeutic application as CCR3 receptor ligands
    Patent number: 8420636
    Abstract: The present invention relates to pyrrolidinyl-alkyl-amide derivatives of formula (I) or (IA) wherein the variables are as defined herein, to their preparation and to their therapeutic use as CCR3 receptor ligands.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: April 16, 2013
    Assignee: Sanofi
    Inventors: Agnes Behr, Sandor Batori, Veronika Bartane Bodor, Zoltan Szlavik, Imre Bata, Katalin Urban-Szabo, Zoltan Kapui, Endre Mikus
  • Compounds
    Patent number: 8338411
    Abstract: The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates, N-oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates, N-oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates, N-oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates, N-oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: December 25, 2012
    Assignee: Sanofi
    Inventors: Edit Susan, Kinga Boer, Zoltan Kapui, Geza Timari, Sandor Batori, Zoltan Szlavik, Endre Mikus, Judit Vargane Szeredi, Michel Finet, Katalin Urban Szabo, Tibor Szabo
  • Aminoquinoline derivatives and their use as adenosine A3 ligands
    Patent number: 8071601
    Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (I).
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: December 6, 2011
    Assignee: Sanofi-Aventis
    Inventors: Peter Aranyi, Sandor Batori, Geza Timari, Kinga Boer, Zoltan Kapui, Endre Mikus, Katalin Urban-Szabo, Katalin Gerber, Judit Vargane Szeredi, Michel Finet
  • Amino-alkyl amide derivatives as CCR3 receptor ligands
    Patent number: 8044078
    Abstract: The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: October 25, 2011
    Assignee: Sanofi-Aventis
    Inventors: Agnes Pappne Behr, Zoltan Kapui, Peter Aranyi, Sandor Batori, Veronika Bartane Bodor, Lajos T. Nagy, Mihalyne Santa, legal representative, Marton Varga, Endre Mikus, Katalin Urban-Szabo, Judit Vargane Szeredi, Tibor Szabo, Edit Susan, Marianna Kovacs
  • PYRROLIDINYL-ALKYL-AMIDE DERIVATIVES, THEIR PREPARATION, AND THEIR THERAPEUTIC APPLICATION AS CCR3 RECEPTOR LIGANDS
    Publication number: 20110144104
    Abstract: The present invention relates to pyrrolidinyl-alkyl-amide derivatives of formula (I) or (IA) wherein the variables are as defined herein, to their preparation and to their therapeutic use as CCR3 receptor ligands.
    Type: Application
    Filed: January 26, 2011
    Publication date: June 16, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Agnes BEHR, Sandor BATORI, Veronika BARTANE BODOR, Zoltan SZLAVIK, Imre BATA, Katalin URBAN-SZABO, Zoltan KAPUI, Endre MIKUS
  • AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
    Publication number: 20110112092
    Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (I).
    Type: Application
    Filed: January 18, 2011
    Publication date: May 12, 2011
    Applicant: sanofi-aventis
    Inventors: Peter ARANYI, Sandor BATORI, Geza TIMARI, Kinga BOER, Zoltan KAPUI, Endre MIKUS, Katalin URBAN-SZABO, Katalin GERBER, Judit VARGANE SZEREDI, Michel FINET
  • PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS
    Publication number: 20110059964
    Abstract: The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
    Type: Application
    Filed: February 3, 2010
    Publication date: March 10, 2011
    Applicant: sanofi-aventis
    Inventors: Michel Aletru, Peter Aranyi, Maria Balogh, Sandor Batori, Judit Bence, Philippe Bovy, Zoltan Kapui, Endre Mikus, Claudie Namane, Christophe Philippo, Tibor Szabo, Zsuzsanna Tomoskozi, Katalin Urban-Szabo
  • AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
    Publication number: 20110009626
    Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (VI?), (VII?) and (VIII?) and their preparation.
    Type: Application
    Filed: August 11, 2010
    Publication date: January 13, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Peter ARANYI, Sandor BATORI, Geza TIMARI, Kinga BOER, Zoltan KAPUI, Endre MIKUS, Katalin URBAN-SZABO, Katalin GERBER, Judit VARGANE SZEREDI, Michel FINET
  • Aminoquinoline derivatives and their use as adenosine A3 ligands
    Patent number: 7799922
    Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (I), within those preferably to the antagonists, including a salt, solvate or isomer (tautomer, desmotrop, and optically active isomer) thereof, to a pharmaceutical composition containing the ligand, to the use of the ligand, to its preparation, and intermediates of the ligand of the general formula (II?), (III?), (IV?), (V?), (VI?), (VII?), (VIII?) and (XIII?) and their preparation.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: September 21, 2010
    Assignee: sanofi-aventis
    Inventors: Peter Aranyi, Sandor Batori, Geza Timari, Kinga Boer, Zoltan Kapui, Endre Mikus, Katalin Urban-Szabo, Katalin Gerber, Judit Vargane Szeredi, Michel Finet
  • NEW COMPOUNDS
    Publication number: 20100216786
    Abstract: The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates, N-oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates, N-oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates, N-oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates, N-oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.
    Type: Application
    Filed: December 4, 2009
    Publication date: August 26, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Edit SUSAN, Kinga BOER, Zoltan KAPUI, Geza TIMARI, Sandor BATORI, Endre MIKUS, Judit VARGANE SZEREDI, Michel FINET, Katalin URBAN-SZABO, Tibor SZABO
  • Triazolo-quinolin derivatives useful as adenosine receptor ligands
    Patent number: 7713992
    Abstract: The present invention relates to adenosine A3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: May 11, 2010
    Assignee: sanofi-aventis
    Inventors: Peter Aranyi, Laszlo Balazs, Sandor Batori, Judit Bence, Kinga Boer, Felix Hajdu, Zoltan Kapui, Endre Mikus, Tibor Szabo, Lajos T. Nagy, Geza Timari, Katalin Urban-Szabo, Erzsebet Walcz
  • Imidazoquinoline derivatives as adenosine A3 receptor ligands
    Patent number: 7709489
    Abstract: This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A3 receptor ligand preferably an antagonist.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: May 4, 2010
    Assignee: sanofi-aventis
    Inventors: Peter Aranyi, Laszlo Balazs, Maria Balogh, Sandor Batori, Lajos T. Nagy, Geza Timari, Kinga Boer, Zoltan Kapui, Endre Mikus, Katalin Gerber, Judit Vargane Szeredi, Katalin Urban-Szabo, Erzsebet Walcz
  • Pyrazole derivatives and use thereof as orexin receptor antagonists
    Patent number: 7659298
    Abstract: The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: February 9, 2010
    Assignee: sanofi-aventis
    Inventors: Michel Aletru, Peter Aranyi, Maria Balogh, Sandor Batori, Judit Bence, Philippe Bovy, Zoltan Kapui, Endre Mikus, Claudie Namane, Christophe Philippo, Tibor Szabo, Zsuzsanna Tomoskozi, Katalin Urban-Szabo
  • AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
    Publication number: 20090247745
    Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (I), within those preferably to the antagonists, including a salt, solvate or isomer (tautomer, desmotrop, and optically active isomer) thereof, to a pharmaceutical composition containing the ligand, to the use of the ligand, to its preparation, and intermediates of the ligand of the general formula (II?), (III?), (IV?), (V?), (VI?), (VII?), (VIII?) and (XIII?) and their preparation.
    Type: Application
    Filed: June 15, 2009
    Publication date: October 1, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Peter ARANYI, Sandor BATORI, Geza TIMARI, Kinga BOER, Zoltan KAPUI, Endre MIKUS, Katalin URBAN-SZABO, Katalin GERBER, Judit VARGANE SZEREDI, Michel FINET
  • Aminoquinoline derivatives and their use as adenosine A3 ligands
    Patent number: 7547696
    Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (I), within those preferably to the antagonists, including a salt, solvate or isomer (tautomer, desmotrop, and optically active isomer) thereof, to a pharmaceutical composition containing the ligand, to the use of the ligand, to its preparation, and intermediates of the ligand of the general formula (II?), (III?), (IV?), (V?), (VI?), (VII?), (VIII?) and (XIII?) and their preparation.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: June 16, 2009
    Assignee: sanofi-aventis
    Inventors: Peter Aranyi, Sandor Batori, Geza Timari, Kinga Boer, Zoltan Kapui, Endre Mikus, Katalin Urban-Szabo, Katalin Gerber, Judit Vargane Szeredi, Michel Finet
  • New amino-alkyl-amide derivatives as CCR3 receptor ligands
    Publication number: 20080293745
    Abstract: The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.
    Type: Application
    Filed: March 18, 2008
    Publication date: November 27, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Agnes PAPPNE BEHR, Zoltan KAPUI, Peter ARANYI, Sandor BATORI, Veronika BARTANE BODOR, Lajos T. NAGY, Mihalyne Santa, Marton VARGA, Gyorgy FERENCZY, Endre MIKUS, Katalin URBAN-SZABO, Judit VARGANE SZEREDI, Tibor SZABO, Erzsebet WALCZ
  • New amino-alkyl-amide derivatives as CCR3 receptor ligands
    Publication number: 20080287434
    Abstract: The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.
    Type: Application
    Filed: March 19, 2008
    Publication date: November 20, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Agnes PAPPNE BEHR, Zoltan KAPUI, Peter ARANYI, Sandor BATORI, Veronika BARTANE BODOR, Lajos T. NAGY, Mihalyne T. Santa, Marton VARGA, Gyorgy FERENCZY, Endre MIKUS, Katalin URBAN-SZABO, Judit VARGANE SZEREDI, Erzsebet WALCZ, Edit SUSAN
  • New amino-alkyl-amide derivatives as CCR3 receptor ligands
    Publication number: 20080280961
    Abstract: The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.
    Type: Application
    Filed: March 19, 2008
    Publication date: November 13, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Agnes PAPPNE BEHR, Zoltan KAPUI, Peter ARANYI, Sandor BATORI, Veronika BARTANE BODOR, Lajos T. NAGY, Mihalyne Santa, Marton VARGA, Endre MIKUS, Katalin URBAN-SZABO, Judit VARGANE SZEREDI, Tibor SZABO, Edit SUSAN, Marianna KOVACS
  • New amino-alkyl-amide derivatives as CCR3 receptor ligands
    Publication number: 20080280963
    Abstract: The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.
    Type: Application
    Filed: March 19, 2008
    Publication date: November 13, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Agnes PAPPNE BEHR, Zoltan KAPUI, Peter ARANYI, Sandor BATORI, Veronika BARTANE BODOR, Lajos T. NAGY, Mihalyne Santa, Marton VARGA, Endre MIKUS, Katalin URBAN-SZABO, Judit VARGANE SZEREDI, Tibor SZABO, Edit SUSAN, Marianna KOVACS
  • IMIDAZOQUINOLINE DERIVATIVES AS ADENOSINE A3 RECEPTOR LIGANDS
    Publication number: 20080255110
    Abstract: This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A3 receptor ligand preferably an antagonist.
    Type: Application
    Filed: June 17, 2008
    Publication date: October 16, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Peter ARANYI, Laszlo BALAZS, Maria BALOGH, Sandor BATORI, Lajos T. NAGY, Geza TIMARI, Kinga BOER, Zoltan KAPUI, Endre MIKUS, Katalin GERBER, Judit VARGANE SZEREDI, Katalin URBAN-SZABO, Erzsebet WALCZ