Patents by Inventor Eng Jom Aw

Eng Jom Aw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of amplification for increasing the sensitivity of detecting nucleic acid-probe target hybrids
    Publication number: 20020155456
    Abstract: The present invention provides a method for simplifying and significantly enhancing the sensitivity of nucleic acid hybridization assays. A method is described whereby a single-stranded primary nucleic acid sequence that includes a region of sequences complementary to a single-stranded target nucleic acid sequence is hybridized to the target molecule. Stability of the double-stranded complex thereby formed can be enhanced by using RNA as the probe if DNA is the target or DNA as the probe if RNA is the target. The probe-target complex is subsequently immunocaptured for detention. After washing away extraneous material, a secondary nucleic acid sequence containing many repeating sequence units is hybridized to the probe component of the immobilized probe-target complex. Detection occurs following hybridization of many labelled nucleic acid sequence probes to each of the repeating sequence units of a nucleic acid amplification probe.
    Type: Application
    Filed: August 27, 2001
    Publication date: October 24, 2002
    Inventors: Sithian Pandian, Eng Jom Aw, David I. Smith
  • Polynucleotide probe and kit for amplifying signal detection in hybridization assays
    Patent number: 6306657
    Abstract: The present invention provides a method for simplifying and significantly enhancing the sensitivity of nucleic acid hybridization assays. A method is described whereby a single-stranded primary nucleic acid sequence that includes a region of sequences complementary to a single-stranded target nucleic acid sequence is hybridized to the target molecule. Stability of the double-stranded complex thereby formed can be enhanced by using RNA as the probe if DNA is the target or DNA as the probe if RNA is the target. The probe-target complex is subsequently immunocaptured for detection. After washing away extraneous material, a secondary nucleic acid sequence containing many repeating sequence units is hybridized to the probe component of the immobilized probe-target complex. Detection occurs following hybridization of many labelled nucleic acid sequence probes to each of the repeating sequence units of a nucleic acid amplification probe.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: October 23, 2001
    Assignee: Kalyx Biosciences, Inc.
    Inventors: Sithian Pandian, Eng Jom Aw, David I. Smith
  • Device and method of use for detection of bacterial lipopolysaccharides
    Patent number: 5888754
    Abstract: This invention relates to a device comprising a hydrophobic solid support coated with a chemical that can capture bacterial lipopolysaccharides (LPS). This invention also relates to the use of such a device in an immunoassay for the detection of microorganisms. This invention also relates to the incorporation of such a device into a diagnostic kit.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: March 30, 1999
    Assignee: Kalyx Biosciences Inc.
    Inventors: Sithian Pandian, Eng Jom Aw, David I. Smith