Patents by Inventor Eng Lo

Eng Lo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Annexin A2 and tissue plasminogen activator for treating vascular disease
    Patent number: 9314499
    Abstract: The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme plasmin for clot lysis. The present invention combines tPA with recombinant Annexin A2 resulting in thrombolysis without hemorrhagic transformation at delayed times after stroke. This embodiment allows the administration of a lower, non-neurotoxic, tPA dose. Our results suggest this novel combination for stroke therapy may greatly improve both efficacy and safety, and prolong tPA therapeutic time window.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: April 19, 2016
    Assignee: The General Hospital Corporation
    Inventors: Xiaoying Wang, Eng Lo
  • Annexin A2 and Tissue Plasminogen Activator For Treating Vascular Disease
    Publication number: 20140227350
    Abstract: The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme plasmin for clot lysis. The present invention combines tPA with recombinant Annexin A2 resulting in thrombolysis without hemorrhagic transformation at delayed times after stroke. This embodiment allows the administration of a lower, non-neurotoxic, tPA dose. Our results suggest this novel combination for stroke therapy may greatly improve both efficacy and safety, and prolong tPA therapeutic time window.
    Type: Application
    Filed: March 5, 2014
    Publication date: August 14, 2014
    Inventors: Xiaoying Wang, Eng Lo
  • COMPOSITIONS AND METHODS FOR TREATING VASCULAR DISEASE
    Publication number: 20110129526
    Abstract: The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme plasmin for clot lysis. The present invention combines tPA with recombinant Annexin A2 resulting in thrombolysis without hemorrhagic transformation at delayed times after stroke. This embodiment allows the administration of a lower, non-neurotoxic, tPA dose. Our results suggest this novel combination for stroke therapy may greatly improve both efficacy and safety, and prolong tPA therapeutic time window.
    Type: Application
    Filed: February 19, 2009
    Publication date: June 2, 2011
    Inventors: Xiaoying Wang, Eng Lo
  • Methods and compositions for protection against thrombolysis associated reperfusion injury
    Publication number: 20060263351
    Abstract: The invention relates to products and methods for reducing cerebral hemorrhage and edema, which can be negative side-effects of thrombolytic therapies with tissue plasminogen activator (tPA) and/or urokinase plasminogen activator (uPA).
    Type: Application
    Filed: December 22, 2003
    Publication date: November 23, 2006
    Applicant: The General Hospital Corporation
    Inventors: Eng Lo, Xiaoying Wang, G. William Rebeck, Ken Arai
  • High-flow oxygen delivery system and methods of use thereof
    Publication number: 20060201504
    Abstract: A device and method of its use for the treatment or prevention of an acute ischemic condition by administering high concentrations of oxygen or an oxygen- containing gas at normobaric pressure and a flow rate of 10 L/min or greater.
    Type: Application
    Filed: March 8, 2005
    Publication date: September 14, 2006
    Inventors: Aneesh Singhal, A. Sorensen, Dean Hess, Eng Lo, Walter Koroshetz