Patents by Inventor Engin Toksoez

Engin Toksoez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES AGAINST HUMAN CCN1 AND USES THEREOF
    Publication number: 20120258112
    Abstract: Disclosed herein are methods for the recombinant expression of mammalian cell membrane-bound human CCN1 or a CCN1 domain thereof in mammalian cells, comprising transforming a mammalian host cell with a vector encoding CCN1 or a CCN1 domain thereof C-terminally fused to a mammalian cell transmembrane domain (CCN1 fusion protein), expressing said CCN1 or CCN1 domain fusion protein in said host cell, and recovering said membrane bound CCN1 or said CCN1 domain thereof. Disclosed herein is the use of such membrane bound CCN1 and domain for the generation of corresponding antibodies. Antibodies against human CCN1 are useful for the treatment of diseases.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 11, 2012
    Inventors: Hendrik Knoetgen, Hans-Willi Krell, Sandra Miller, Jens Niewoehner, Dirk Ponsel, Engin Toksoez
  • Antibodies against human CCN1 and uses thereof
    Patent number: 8207307
    Abstract: Disclosed herein are methods for the recombinant expression of mammalian cell membrane-bound human CCN1 or a CCN1 domain thereof in mammalian cells, comprising transforming a mammalian host cell with a vector encoding CCN1 or a CCN1 domain thereof C-terminally fused to a mammalian cell transmembrane domain (CCN1 fusion protein), expressing said CCN1 or CCN1 domain fusion protein in said host cell, and recovering said membrane bound CCN1 or said CCN1 domain thereof. Disclosed herein is the use of such membrane bound CCN1 and domain for the generation of corresponding antibodies. Antibodies against human CCN1 are useful for the treatment of diseases.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: June 26, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hendrik Knoetgen, Hans-Willi Krell, Sandra Miller, Jens Niewoehner, Dirk Ponsel, Engin Toksoez
  • Antibodies Against Human CCN1 and Uses Thereof
    Publication number: 20100310567
    Abstract: Disclosed herein are methods for the recombinant expression of mammalian cell membrane-bound human CCN1 or a CCN1 domain thereof in mammalian cells, comprising transforming a mammalian host cell with a vector encoding CCN1 or a CCN1 domain thereof C-terminally fused to a mammalian cell transmembrane domain (CCN1 fusion protein), expressing said CCN1 or CCN1 domain fusion protein in said host cell, and recovering said membrane bound CCN1 or said CCN1 domain thereof. Disclosed herein is the use of such membrane bound CCN1 and domain for the generation of corresponding antibodies. Antibodies against human CCN1 are useful for the treatment of diseases.
    Type: Application
    Filed: June 3, 2010
    Publication date: December 9, 2010
    Inventors: HENDRIK KNOETGEN, HANS-WILLI KRELL, SANDRA MILLER, JENS NIEWOEHNER, DIRK PONSEL, ENGIN TOKSOEZ