Patents by Inventor Engui ZHAO

Engui ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aie luminogens for visualization and treatment of cancer
    Patent number: 10935552
    Abstract: The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 2, 2021
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Engui Zhao, Chen Gui, Meijuan Jiang, Haiqin Deng, Wai Tung Leung, Zhiming Wang, Yueyue Zhao, Tsz Kin Kwok, Lucia Viglianti, Ni Xie
  • AIE LUMINOGENS FOR VISUALIZATION AND TREATMENT OF CANCER
    Publication number: 20180156811
    Abstract: The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 7, 2018
    Inventors: Benzhong TANG, Engui ZHAO, Chen GUI, Meijuan JIANG, Haiqin DENG, Wai Tung LEUNG, Zhiming WANG, Yueyue ZHAO, Tsz Kin KWOK, Lucia VIGLIANTI, Ni XIE
  • Photostable AIE luminogens for specific mitochondrial imaging and its method of manufacturing thereof
    Patent number: 9315465
    Abstract: AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: April 19, 2016
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Yuning Hong, Sijie Chen, Wai Tung Leung, Engui Zhao, Haiqin Deng
  • PHOTOSTABLE AIE LUMINOGENS FOR SPECIFIC MITOCHONDRIAL IMAGING AND ITS METHOD OF MANUFACTURING THEREOF
    Publication number: 20140212359
    Abstract: AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 31, 2014
    Applicant: The Hong Kong University of Science and Technology
    Inventors: Benzhong TANG, Yuning HONG, Sijie CHEN, Wai Tung LEUNG, Engui ZHAO, Haiqin DENG