Patents by Inventor Ennio Ongini

Ennio Ongini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitrooxy Derivatives of Glucocorticoids
    Publication number: 20080221073
    Abstract: The invention relates to new steroids nitrooxyderivatives, to topical pharmaceutical formulations thereof, and their use for treating skin or mucosal membrane diseases or disorders. These new steroids nitrooxyderivatives have an improved pharmacological activity and enhanced local tolerability.
    Type: Application
    Filed: August 4, 2006
    Publication date: September 11, 2008
    Inventors: Francesca Benedini, Ennio Ongini, Antonio Guglietta, Daniel Palop, Marta Princep
  • Drugs for chronic pains
    Publication number: 20080113950
    Abstract: Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A-(B)b0-(C)o0-N02 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R-TI-, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from aminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
    Type: Application
    Filed: November 14, 2007
    Publication date: May 15, 2008
    Inventors: Piero Soldato, Ennio Ongini
  • Statin derivatives
    Publication number: 20080096908
    Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
    Type: Application
    Filed: October 5, 2007
    Publication date: April 24, 2008
    Inventors: Francesca Benedini, Ennio Ongini, Piero Del Soldato
  • Statin derivatives
    Publication number: 20080090857
    Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
    Type: Application
    Filed: October 5, 2007
    Publication date: April 17, 2008
    Inventors: Francesca Benedini, Ennio Ongini, Piero Del Soldato
  • PROSTAGLANDIN DERIVATIVES
    Publication number: 20080058392
    Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 6, 2008
    Inventors: Ennio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
  • Statin derivatives
    Patent number: 7297808
    Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: November 20, 2007
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Ennio Ongini, Piero Del Soldato
  • Process for Preparing Nitrooxy Esters, Nitrooxy Thioesters Nitrooxy Carbonates and Nitrooxy Thiocarbinates, Intermediates Useful in Said Process and Preparation Thereof
    Publication number: 20070238882
    Abstract: The present invention relates to a process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates of compounds having at least an hydroxyl or thiol functional group, according to the following reaction scheme The invention also relates to intermediates useful in said process and to their preparation.
    Type: Application
    Filed: February 2, 2005
    Publication date: October 11, 2007
    Inventors: Nicoletta Almirante, Massimiliano Ferrario, Ennio Ongini
  • Drugs for chronic pains
    Publication number: 20070161576
    Abstract: Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A-(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R-T1-, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from aminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
    Type: Application
    Filed: February 14, 2007
    Publication date: July 12, 2007
    Inventors: Piero Soldato, Ennio Ongini
  • ACE inhibitor derivatives
    Patent number: 7217733
    Abstract: ACE inhibitor nitroderivatives of formula (I): A—(X1—ONO2)s ??(I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular and renal diseases and inflammatory processes.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: May 15, 2007
    Assignee: Nicox, S.A.
    Inventors: Nicoletta Almirante, Ennio Ongini, Piero Del Soldato
  • Drugs for chronic pains
    Patent number: 7199141
    Abstract: Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R—T1—, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from anminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: April 3, 2007
    Assignee: Nicox S.A.
    Inventors: Piero Del Soldato, Ennio Ongini
  • Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive
    Publication number: 20070072854
    Abstract: The present invention relates to -adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
    Type: Application
    Filed: December 1, 2004
    Publication date: March 29, 2007
    Inventors: Piero Del Soldato, Francesca Benedini, Ennio Ongini
  • Statin derivatives
    Publication number: 20070072942
    Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
    Type: Application
    Filed: November 1, 2006
    Publication date: March 29, 2007
    Inventors: Francesca Benedini, Ennio Ongini, Piero Soldato
  • Nitrooxyderivatives of antihypertensive drugs
    Publication number: 20070060586
    Abstract: The present invention relates to ?-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
    Type: Application
    Filed: December 1, 2004
    Publication date: March 15, 2007
    Inventors: Piero Del Soldato, Francesca Benedini, Ennio Ongini
  • Captopril derivatives
    Patent number: 7169805
    Abstract: Captopril nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment or prophylaxis of cardiovascular, inflammatory and renal diseases.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: January 30, 2007
    Assignee: Nicox S.A.
    Inventors: Nicoletta Almirante, Ennio Ongini, Piero Del Soldato
  • Statin derivatives
    Patent number: 7166638
    Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: January 23, 2007
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Ennio Ongini, Piero Del Soldato
  • Probucol nitro-derivatives
    Patent number: 7166605
    Abstract: Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: January 23, 2007
    Assignee: Nicox, S.A.
    Inventors: Piero Del Soldato, Giancarlo Santus, Ennio Ongini
  • Nitoroxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases
    Publication number: 20060276523
    Abstract: Angiotensin II receptor blocker nitroderivatives of formula (I): R—(Y—ONO2)s??(I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular, renal and chronic liver diseases and inflammatory processes.
    Type: Application
    Filed: July 20, 2004
    Publication date: December 7, 2006
    Inventors: Nicoletta Almirante, Piero Del Soldato, Ennio Ongini
  • Drugs for chronic pain
    Publication number: 20060270608
    Abstract: The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I): R—NR1c—(K)k0—(B)b0—(C)c0—NO2??(I) wherein c0, b0 and k0 are 0 or 1; R is the radical of an analgesic drug for chronic pain, for instance neurophatic pain; R1c is H or alkyl with from 1 to 5 carbon atoms; B is such that its precursor is selected from amino acids, hydroxy acids, polyalcohol, compounds; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
    Type: Application
    Filed: December 3, 2003
    Publication date: November 30, 2006
    Inventors: Ennio Ongini, Nicoletta Almirante, Piero Del Soldato
  • Probucol derivatives
    Publication number: 20060167003
    Abstract: Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
    Type: Application
    Filed: March 19, 2003
    Publication date: July 27, 2006
    Inventors: Piero Del Soldato, Giancarlo Santus, Ennio Ongini
  • New corticosteroids
    Publication number: 20060052594
    Abstract: Nitrooxy derivatives of steroidal compounds of general formula B—X1—NO2??(I) or esters or salts thereof, wherein: B is a steroidal radical, X1 is a bivalent linking group comprising an aromatic or heterocyclic ring.
    Type: Application
    Filed: January 16, 2003
    Publication date: March 9, 2006
    Inventors: Piero Del Soldato, Ennio Ongini