Abstract: Device for the treatment of tissue calcification, in particular aortic valve leaflets, characterized by the fact that it comprises a first ultrasound emission source that is adapted to provide ultrasound waves with MHz frequencies and a second ultrasound emission source that is adapted to provide ultrasound waves with KHZ frequencies, both MHz and KHz waves being used for the said treatment. The invention also includes a method for the treatment of tissue calcification that is characterized by the simultaneous use of ultrasound waves with MHz frequencies and ultrasound waves with KHz frequencies.

Abstract: Tissue ablation system for the internal treatment of parenchymal organs, hollow anatomical conduits or blood vessels (7); said system comprising an Electromagnetic (EM) wave generator (1) and a catheter (8-14, 16-40) with an active distal end; characterized by the fact that said generator (1) includes at least two EM wave outputs (3-6) and is adapted to provide three types of EM waves through said outputs (3-6), namely Radiofrequency (RF), Microwave (MW) and Laser (LS); said generator (1) furthermore comprising a processing unit that is programmed, among other things, to emit all three EM waves at the same time and control the interaction among them.

Abstract: Transcatheter delivery system for a self-expandable heart valve prosthesis (29) comprising a handle (17, 17?), a hollow shaft (6) a distal tip (1, 1?, 1??) and an actuation mechanism for moving a valve prosthesis (29) towards said distal tip (1, 1?, 1??) or said handle (17, 17?), said hollow shaft (6) being adapted to slidingly receive a compressed valve prosthesis (29); the system being characterized by the fact that it includes a valve prosthesis crimping tool that comprises a hollow conical element (21), a detachable transfer tube (24) and a pulling device (26); said conical element (21) being adapted to let a valve prosthesis (29) in an expanded state enter the conical element (21) through its basis and enter said transfer tube (24) in a compressed state, said valve prosthesis (29) being pulled by said pulling device (26) when crossing said conical element (21) and entering said transfer tube (24), said transferring tube (24) being adapted to be temporarily connected to said conical element (21).

Abstract: The invention concerns a resection apparatus for native or bioprosthetic heart valves (6) comprising a leaflet grasping system (5,8) and a leaflet cutting device (9), said grasping system (5,8) and said cutting device (9) being coaxially and longitudinally movable relatively to each other and wherein said grasping system (5,8) is longitudinally oriented, characterized by the fact that the grasping system (5,8) comprises a fixed portion (5) and a rotating portion (8); said fixed portion (5) being adapted to grasp a leaflet face (6b) and said rotating portion (8) being adapted to grasp the opposite leaflet face (6a).

Abstract: Transcatheter device for the treatment of calcified native heart valve leaflets comprising an outer hollow shaft (5), an inner hollow shaft (4) slidingly contained within said outer shaft (5) and an axle body (6) slidingly contained within said inner shaft (4); wherein the device comprises a commissure debridement system (7), located at the distal end of the axle body (6), that is made of at least two radially expandable arms (7) that are adapted to be inserted in and aligned with native commissures.

Abstract: The invention concerns the treatment of bioprosthetic tissues a Cyclodextrin, preferably in association with Ethanol.

Abstract: Prosthetic heart valve leaflet with a fixed end and a free end characterized by the fact that it has a variable thickness.

Abstract: A transcatheter temporary valve prosthesis for blood vessel comprising an expandable support structure (5?), a valve (7), a filter (12) and a conveyor (6); said support structure (5?) forming a tubular shape when expanded, with a distal and a proximal end, said valve (7) being located at said distal end and said conveyor (6) extending within said support structure (5), from said proximal to said distal end and including a central passage that is adapted to act as an introducer for other devices.

Abstract: An intra-vessel transcatheter filter device (1) designed to capture and remove emboli, thus preventing distal embolization, comprising: • a tubular filter (2) comprising a flexible porous material and defined by a distal element and a proximal element, namely a main body (3) and a funnel (4); i. said main body (3) having a length adapted to extend within a suitable vessel zone; said main body (3) comprising: a) a distal end (5) that is adapted to be radially coupled with said zone and hermetically sealed to it when the device is in an active configuration, said distal end (5) being provided of selectively actionable closure means so that said distal end is designed to be open when the device is in an active configuration and closed before the device retraction, b) a proximal end (6); ii. said funnel (4) forming an extension of said main body (3), with the funnel base located at said proximal end (6). • a support structure assembly (8) comprising: i.

Abstract: Electromagnetic (EM) tissue ablation device comprising an EM field generator unit, at least two coaxial elongated elements (i.e. an external one and an internal one) and a mechanism for varying the EM field, wherein said internal element is a part of said generator and said mechanism being adapted to vary the EM field for a specific tissue area.

Abstract: Device for the treatment of tissue calcification, in particular aortic valve leaflets, characterized by the fact that it comprises a first ultrasound emission source that is adapted to provide ultrasound waves with MHz frequencies and a second ultrasound emission source that is adapted to provide ultrasound waves with KHz frequencies, both MHz and KHz waves being used for the said treatment. The invention also includes a method for the treatment of tissue calcification that is characterized by the simultaneous use of ultrasound waves with MHz frequencies and ultrasound waves with KHz frequencies.

Abstract: The invention concerns the treatment of bioprosthetic tissues a Cyclodextrin, preferably in association with Ethanol.

Abstract: Prosthetic heart valve leaflet with a fixed end and a free end characterized by the fact that it has a variable thickness.

Abstract: An expandable stent-valve has a stent component and a valve component, preferably an aortic valve component, a mitral valve component or a tricuspid valve component. The stent has, an outer surface area structured in a manner such that the surface area has a higher coefficient of friction between the outer surface and a duct wall than an untreated surface area of the stent component. The surface area is preferably structured with micro-incisions or micro-grooves.

Abstract: Atrio-ventricular valve stent (1) having a tubular shape, with a sub annular anterior side (2), a sub annular posterior side (3) and sub annular lateral sides (13), the sub annular anterior side (2) comprising a self-folding native leaflet engagement member (4-9) that forms a straight extension of said sub annular anterior side (2) when the stent (1) is collapsed and that is folded on itself when the stent (1) is in an expanded state; said engagement member (4-9) forming an integral part of the stent (1) and wherein each sub annular lateral side (13) is longer than said sub annular anterior side (2) when the stent (1) is in an expanded state.

Abstract: Crimping device (1) for reducing the diameter of collapsible valves, said device (1) including at least two independent cylindrical crimping units (2, 3, 4) that are each adapted to crimp a different specific part of a valve, independently from the other crimping unit(s), each of said unit (2, 3, 4) comprising a diaphragm rotation crimping mechanism that includes crimping jaws, and wherein each unit (2, 3, 4) comprises an actuator for activating said mechanism, characterized by the fact that said actuator is a handling screw (51, 61, 71) that is tangentially fixed to the external surface of the cylindrical crimping unit (2, 3, 4).

Abstract: A prosthetic valve, preferably an expandable prosthetic valve, having a valve component (3), preferably a mitral valve component, made of a single functional leaflet (6) wherein the prosthetic valve (1) comprises at least two tissue supports (4?, 4?,4??,4??) attachable to an inner surface (5) of a stent component (2), wherein at least one tissue support (4?, 4?,4??,4??) comprises at least one attachment area (7?, 7?), at least a section of the attachment area extending essentially inwardly from the inner surface (5), wherein said leaflet (6) is attached to at least one tissue support (4?, 4?,4??,4??) at the section of said attachment area(s) (7?, 7?) such that the leaflet (6) is arranged between said attachment area(s) (7?,7?) or integrally formed with one tissue support (4?,4?,4??,4??) and attached to the second tissue support (4?,4?,4??,4??) at the section of the attachment area(s) (7?,7?).

Abstract: A cardiac stent-valve (1), preferably a mitral stent-valve, comprising a stent component (2) and a valve component (3), wherein the stent component (2) comprises an inflow end (4) and an outflow end (5) and a wall between the inflow (4) and the outflow end (5), and wherein the valve component (3) is made of one single leaflet (6); the periphery of said single leaflet (6) being partially attached or attachable to the stent component (2) along at least fixation lines (7?, 7?), characterized in that said two fixation lines (7?) are at least partially inclined with respect to an annular plane of said valve perpendicular to a flow direction (A) through the stent-valve (1) and wherein the third fixation line (7?) runs parallel with respect to said plane.

Abstract: Medical device for transcatheter heart valve repair comprising a grasping tweezer (1) and a plicating tweezer (2), said grasping tweezer (1) being adapted to grasp a leaflet rim (3) and said plicating tweezer (2) comprising two rotatable flaps (4,5) and a central shaft (6) around which said flaps (4,5) may rotate in a “butterfly manner”, in such a way that the plicating tweezer (2) may adopt a closed or an open configuration. The invention also relates to a method for using this medical device.

Abstract: Transcatheter device for the treatment of calcified native heart valve leaflets comprising an outer hollow shaft (5), an inner hollow shaft (4) slidingly contained within said outer shaft (5) and an axle body (6) slidingly contained within said inner shaft (4); wherein the device comprises a commissure debridement system (7), located at the distal end of the axle body (6), that is made of at least two radially expandable arms (7) that are adapted to be inserted in and aligned with native commissures.