Abstract: The present invention relates to systems and methods for improvement of physiological function in an individual with a spinal cord injury via electrical stimulation of the spinal cord. A 3D model of the spinal cord is used to determine an initial position for an electrode array to deliver stimulation. Spinal cord electrical stimulation is configurable to target different physiological functions with surgical implantation of the neurostimulator at a singular location. Such systems and methods include (i) anatomical specificity to target the appropriate region of the spinal cord for stimulation, (ii) electrical specificity to provide the appropriate stimulation by delivery method, frequency, pulse duration, and other factors, and (iii) physiological specificity to evoke, suppress, increase, or decrease a specific physiological result.

Abstract: An automated segmentation system for medical imaging data segments data into muscle and fat volumes, and separates muscle volumes into discrete muscle group volumes using a plurality of models of the medical imaging data, and wherein the medical imaging data includes data from a plurality of imaging modalities.

Abstract: Computer-implemented systems and methods for determining epidural spinal stimulation parameters that promote muscle activation use spectral analysis and machine learning techniques to characterize electromyography data.

Abstract: An automated segmentation system for medical imaging data segments data into muscle and fat volumes, and separates muscle volumes into discrete muscle group volumes using a plurality of models of the medical imaging data, and wherein the medical imaging data includes data from a plurality of imaging modalities.

Abstract: Computer-implemented systems and methods for determining epidural spinal stimulation parameters that promote muscle activation use spectral analysis and machine learning techniques to characterize electromyography data.

Abstract: A closed loop system for control of spinal cord epidural stimulation includes a second controller hosting software for receiving, from at least one sensor, physiological data from a subject, generating a stimulation configuration based on the data, and transmitting the configuration to a first controller which operatively causes a neurostimulator to apply the stimulation configuration to the subject, the physiological results of such stimulation are monitored by the at least one sensor.

Abstract: An automated segmentation system for medical imaging data segments data into muscle and fat volumes, and separates muscle volumes into discrete muscle group volumes using a plurality of models of the medical imaging data, and wherein the medical imaging data includes data from a plurality of imaging modalities.

Abstract: Computer-implemented systems and methods for determining epidural spinal stimulation parameters that promote muscle activation use spectral analysis and machine learning techniques to characterize electromyography data.